Synthesis of Daunorubicin Piperonal Derivatives by One-Step Reductive Amination

被引：1
|
作者：
Artyushin, O. I. [1 ]
Brel, V. K. [1 ]
Moiseeva, A. A. [1 ]
机构：
[1] Russian Acad Sci, Nesmeyanov Inst Organoelement Cpds, Moscow 199991, Russia
来源：
MOSCOW UNIVERSITY CHEMISTRY BULLETIN | 2020年 / 75卷 / 02期
基金：
俄罗斯基础研究基金会;
关键词：
anthracycline antibiotics; daunorubicin; reductive amination; aromatic aldehydes; anticancer agents;
D O I：
10.3103/S0027131420020029
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
New N-derivatives of daunorubicin are obtained using aromatic aldehydes by one-step reductive amination. The obtained compounds are found to exhibit a high cytotoxic activity.
引用
收藏
页码：106 / 109
页数：4
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