Actinorhodin production by Streptomyces coelicolor A3(2) in iron-restricted media

被引：30
|
作者：
Coisne, S [1 ]
Béchet, M [1 ]
Blondeau, R [1 ]
机构：
[1] Univ Sci & Technol Lille, Microbiol Lab, F-59655 Villeneuve Dascq, France
来源：
LETTERS IN APPLIED MICROBIOLOGY | 1999年 / 28卷 / 03期
关键词：
Antibiotics; -; Bacteria; Ketones;
D O I：
10.1046/j.1365-2672.1999.00509.x
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Production of the polyketide antibiotic actinorhodin by Streptomyces coelicolor A3(2) was investigated using a defined medium with or without iron supplementation. Iron limitation was found to enhance the intracellular production and export of the pigmented antibiotic. The effect of iron deficiency was particularly pronounced when the bacterium was grown with nitrate instead of ammonium. Analysis of the excreted pigment led to the identification of the lactone form of actinorhodin, gamma-actinorhodin.
引用
收藏
页码：199 / 202
页数：4
相关论文
共 50 条
  • [1] Effect of sucrose on actinorhodin production by Streptomyces coelicolor A3(2)
    Elibol, M
    Mavituna, F
    PROCESS BIOCHEMISTRY, 1998, 33 (03) : 307 - 311
  • [2] A kinetic model for actinorhodin production by Streptomyces coelicolor A3(2)
    Elibol, M
    Mavituna, F
    PROCESS BIOCHEMISTRY, 1999, 34 (6-7) : 625 - 631
  • [3] Production of actinorhodin by Streptomyces coelicolor A3(2) grown in chemostat culture
    Dept. of Ferment. Chem. and Bioeng., Institute of Chemical Technology, Technická 5, 16628 Prague 6, Czech Republic
    不详
    BIOTECHNOL. BIOENG., 6 (577-582):
  • [4] Production of actinorhodin by Streptomyces coelicolor A3(2) grown in chemostat culture
    Melzoch, K
    deMattos, MJT
    Neijssel, OM
    BIOTECHNOLOGY AND BIOENGINEERING, 1997, 54 (06) : 577 - 582
  • [5] Synthetic Promoter Library for Modulation of Actinorhodin Production in Streptomyces coelicolor A3(2)
    Sohoni, Sujata Vijay
    Fazio, Alessandro
    Workman, Christopher T.
    Mijakovic, Ivan
    Lantz, Eliasson
    PLOS ONE, 2014, 9 (06):
  • [6] EFFECT OF INOCULUM TYPE ON ACTINORHODIN PRODUCTION BY STREPTOMYCES-COELICOLOR A3(2)
    ELIBOL, M
    ULGEN, K
    KAMARUDDIN, K
    MAVITUNA, F
    BIOTECHNOLOGY LETTERS, 1995, 17 (06) : 579 - 582
  • [7] Production of actinorhodin-related ''blue pigments'' by Streptomyces coelicolor A3(2)
    Bystrykh, LV
    FernandezMoreno, MA
    Herrema, JK
    Malpartida, F
    Hopwood, DA
    Dijkhuizen, L
    JOURNAL OF BACTERIOLOGY, 1996, 178 (08) : 2238 - 2244
  • [8] GENETICS OF ACTINORHODIN BIOSYNTHESIS BY STREPTOMYCES-COELICOLOR A3(2)
    RUDD, BAM
    HOPWOOD, DA
    JOURNAL OF GENERAL MICROBIOLOGY, 1979, 114 (SEP): : 35 - 43
  • [9] EFFECT OF PERFLUORODECALIN AS AN OXYGEN CARRIER ON ACTINORHODIN PRODUCTION BY STREPTOMYCES-COELICOLOR A3(2)
    ELIBOL, M
    MAVITUNA, F
    APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 1995, 43 (02) : 206 - 210
  • [10] Synthetic RNA Silencing of Actinorhodin Biosynthesis in Streptomyces coelicolor A3(2)
    Uguru, Gabriel C.
    Mondhe, Madhav
    Goh, Shan
    Hesketh, Andrew
    Bibb, Mervyn J.
    Good, Liam
    Stach, James E. M.
    PLOS ONE, 2013, 8 (06):
12345