Role of ovarian reserve markers, antimullerian hormone and antral follicle count, as aneuploidy markers in ongoing pregnancies and miscarriages

Objective: To assess the role of two ovarian reserve markers, antimullerian hormone (AMH) and antral follicle count (AFC), as markers of the background risk for fetal trisomy. Design: Prospective study. Setting: Tertiary referral hospital. Patient(s): Assessment was carried out either in ongoing pregnancies or miscarriages in our center. Intervention(s): AFC was assessed transvaginally during a routine (11-13 weeks) or referral scan. AMH was determined either during the first-trimester maternal serum markers assessment or in cases referred for chorionic villi sampling after the invasive procedure. Main Outcome Measure(s): AMH reference ranges were constructed according to maternal age, and AMH- and AFC-derived ovarian ages were compared among three different cytogenetic groups (normal karyotype, autosomal trisomies, and other chromosomal anomalies) in both ongoing pregnancies and miscarriages. Result(s): In autosomal trisomies, the median AFC-derived ovarian age was 3-5 years above the median maternal age. No differences were observed between AMH-derived ovarian age and maternal age. Conclusion(s): AFC-derived ovarian biologic age reflects a more precise background risk for fetal aneuploidy that is not observed for AMH-derived age. (C) 2015 by American Society for Reproductive Medicine.