Lessons from an anti-DNA autoantibody

被引：13

作者：

Cohen-Solal, Joel ^{[1
]}

Diamond, Betty ^{[1
]}

机构：

[1] Ctr Autoimmune & Musculoskeletal Dis, Feinstein Inst Med Res, Manhasset, NY 11030 USA

来源：

MOLECULAR IMMUNOLOGY | 2011年 / 48卷 / 11期

关键词：

Anti-DNA antibody; Peptide mimetope; B cell tolerance; BCR signaling; SYSTEMIC-LUPUS-ERYTHEMATOSUS; GLUTAMATE-RECEPTOR ANTIBODIES; B-CELL REPERTOIRE; CEREBROSPINAL-FLUID; AUTOIMMUNE-DISEASE; MICE; PATHOGENESIS; ASSOCIATION; IMPAIRMENT; MECHANISMS;

D O I：

10.1016/j.molimm.2010.12.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

R4A is an anti-DNA antibody derived by hybridoma technology from a BALB/c mouse. The study of its properties has helped to elucidate aspects of the physiopathology of Systemic Lupus Erythematosus (SLE). It has been useful to decipher the mechanisms implicated in breaks in B cell self tolerance by B cell extrinsic or B cell intrinsic factors. Furthermore, it illustrates the importance of molecular mimicry in understanding the cellular and molecular effects relevant to some manifestations of neuropsychiatric lupus, as it cross-reacts with the D/E W D/E YS/G peptide sequence present in subunits of the N-methyl n-aspartate receptor (NMDAR). (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：1328 / 1331

页数：4

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