Indoleamine 2,3-dioxygenase vaccination

被引：19
|
作者：
Andersen, Mads Hald [1 ]
Svane, Inge Marie [1 ,2 ]
机构：
[1] Copenhagen Univ Hosp, CCIT, Dept Hematol, Herlev, Denmark
[2] Copenhagen Univ Hosp, Dept Oncol, Herlev, Denmark
来源：
ONCOIMMUNOLOGY | 2015年 / 4卷 / 01期
关键词：
cancer vaccine; CD8; IDO; NSCLC; PD-L1; LUNG-CANCER PATIENTS; CELLS;
D O I：
10.4161/2162402X.2014.983770
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Indoleamine 2,3-dioxygenase (IDO) is an immunoregulatory enzyme. Remarkably, we discovered IDO-specific T cells that can influence adaptive immune reactions in patients with cancer. Further, a recent phase I clinical trial demonstrated long-lasting disease stabilization without toxicity in patients with non-small-cell lung cancer (NSCLC) who were vaccinated with an IDO-derived HLA-A2-restricted epitope.
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页数：3
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