Treg cell-based therapies: challenges and perspectives

被引：408
|
作者：
Raffin, Caroline [1 ]
Vo, Linda T. [1 ]
Bluestone, Jeffrey A. [1 ]
机构：
[1] Univ Calif San Francisco, Ctr Diabet, Sean N Parker Autoimmune Res Lab, San Francisco, CA 94143 USA
来源：
NATURE REVIEWS IMMUNOLOGY | 2020年 / 20卷 / 03期
关键词：
LOW-DOSE INTERLEUKIN-2; VERSUS-HOST-DISEASE; PLURIPOTENT STEM-CELLS; DE-NOVO GENERATION; FACTOR RECEPTOR-II; REGULATORY-CELLS; CUTTING EDGE; EX-VIVO; RHEUMATOID-ARTHRITIS; TGF-BETA;
D O I：
10.1038/s41577-019-0232-6
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Cellular therapies using regulatory T (T-reg) cells are currently undergoing clinical trials for the treatment of autoimmune diseases, transplant rejection and graft-versus-host disease. In this Review, we discuss the biology of T-reg cells and describe new efforts in T-reg cell engineering to enhance specificity, stability, functional activity and delivery. Finally, we envision that the success of T-reg cell therapy in autoimmunity and transplantation will encourage the clinical use of adoptive T-reg cell therapy for non-immune diseases, such as neurological disorders and tissue repair. Therapies based on adoptive cellular transfer of regulatory T (T-reg) cells are currently undergoing clinical trials for autoimmune diseases, graft-versus-host disease and the prevention of transplant rejection. This Review provides an overview of T-reg cell biology and discusses the latest approaches to enhance T-reg cells for therapeutic purposes.
引用
收藏
页码：158 / 172
页数：15
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