Torcetrapib-induced blood pressure elevation is independent of cholesteryl ester transfer protein inhibition and is accompanied by an increase in circulating aldosterone levels

被引:0
|
作者
Forrest, Michael J.
Bloomfield, Daniel
Briscoe, Richard J.
Ehrhart, Juliann
Hershey, James C.
Ma, Xiuying
Peterson, Laurence B.
Siegl, Peter K.
Sinclair, Peter J.
Stevenson, Andra S.
Sun, Shu-Yu
Vargas, Hugo M.
Walker, Matthew
Sparrow, Carl P.
机构
[1] Merck & Co Inc, Rahway, NJ 07065 USA
[2] Merck & Co Inc, West Point, PA USA
[3] Amgen Inc, Thousand Oaks, CA USA
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
4020
引用
收藏
页码:1209 / 1209
页数:1
相关论文
共 36 条
  • [1] Torcetrapib-induced blood pressure elevation is independent of CETP inhibition and is accompanied by increased circulating levels of aldosterone
    Forrest, M. J.
    Bloomfield, D.
    Briscoe, R. J.
    Brown, P. N.
    Cumiskey, A-M
    Ehrhart, J.
    Hershey, J. C.
    Keller, W. J.
    Ma, X.
    McPherson, H. E.
    Messina, E.
    Peterson, L. B.
    Sharif-Rodriguez, W.
    Siegl, P. K. S.
    Sinclair, P. J.
    Sparrow, C. P.
    Stevenson, A. S.
    Sun, S-Y
    Tsai, C.
    Vargas, H.
    Walker, M., III
    West, S. H.
    White, V.
    Woltmann, R. F.
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 2008, 154 (07) : 1465 - 1473
  • [2] Torcetrapib Produces Endothelial Dysfunction Independent of Cholesteryl Ester Transfer Protein Inhibition
    Connelly, Margery A.
    Parry, Tom J.
    Giardino, Edward C.
    Huang, Zhihong
    Cheung, Wai-man
    Chen, Cailin
    Cools, Frank
    Van der Linde, Henk
    Gallacher, David J.
    Kuo, Gee-Hong
    Sarich, Troy C.
    Demarest, Keith T.
    Damiano, Bruce P.
    [J]. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2010, 55 (05) : 459 - 468
  • [3] Fluorophilic pharmacophore for cholesteryl ester transfer protein inhibition: Discovery and demise of torcetrapib
    Ruggeri, Roger B.
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2012, 243
  • [4] Torcetrapib Induces Aldosterone and Cortisol Production by an Intracellular Calcium-Mediated Mechanism Independently of Cholesteryl Ester Transfer Protein Inhibition
    Hu, Xiao
    Dietz, Jessica D.
    Xia, Chunsheng
    Knight, Delvin R.
    Loging, William T.
    Smith, Andrew H.
    Yuan, Haodan
    Perry, David A.
    Keiser, Joan
    [J]. ENDOCRINOLOGY, 2009, 150 (05) : 2211 - 2219
  • [5] Cholesteryl ester transfer protein variants have differential stability but uniform inhibition by torcetrapib
    Lloyd, DB
    Lira, ME
    Wood, LS
    Kurham, LK
    Freeman, TB
    Preston, GM
    Qiu, XY
    Sugarman, E
    Bonnette, P
    Lanzetti, A
    Milos, PM
    Thompson, JF
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (15) : 14918 - 14922
  • [6] Effects of CP-532,623 and Torcetrapib, Cholesteryl Ester Transfer Protein Inhibitors, on Arterial Blood Pressure
    Blasi, Eileen
    Bamberger, Mark
    Knight, Delvin
    Engwall, Mike
    Wolk, Robert
    Winter, Steven
    Betts, Allison
    John-Baptiste, Annette
    Keiser, Joan
    [J]. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2009, 53 (06) : 507 - 516
  • [7] Circulating plasma cholesteryl ester transfer protein activity and blood pressure tracking in the community
    Zachariah, Justin P.
    Pencina, Michael J.
    Lyass, Asya
    Kaur, Guneet
    D'Agostino, Ralph B.
    Ordovas, Jose M.
    Vasan, Ramachandran S.
    [J]. JOURNAL OF HYPERTENSION, 2011, 29 (05) : 863 - 868
  • [8] Inhibition of cholesteryl ester transfer protein by torcetrapib modestly increases macrophage cholesterol efflux to HDL
    Yvan-Charvet, Laurent
    Matsuura, Fumihiko
    Wang, Nan
    Bamberger, Mark J.
    Nguyen, Tu
    Rinninger, Franz
    Jiang, Xian-Cheng
    Shear, Charles L.
    Tall, Alan R.
    [J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2007, 27 (05) : 1132 - 1138
  • [9] Cholesteryl ester transfer protein inhibition and HDL increase: has the dream ended?
    Athyros, Vasilios G.
    Kakafika, Anna
    Tziornalos, Konstantinos
    Karagiannis, Asterios
    Mikhailidist, Dimitri P.
    [J]. EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2008, 17 (04) : 445 - 449
  • [10] Raising high-density lipoprotein in humans through inhibition of cholesteryl ester transfer protein: An initial multidose study of torcetrapib
    Clark, RW
    Sutfin, TA
    Ruggeri, RB
    Willauer, AT
    Sugarman, ED
    Magnus-Aryitey, G
    Cosgrove, PG
    Sand, TM
    Wester, RT
    Williams, JA
    Perlman, ME
    Bamberger, MJ
    [J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2004, 24 (03) : 490 - 497