Detection of oncogenic human papillomavirus in sporadic retinoblastoma

被引:32
|
作者
Palazzi, MA
Yunes, JA
Cardinalli, IA
Stangenhaus, GP
Brandalise, SR
Ferreira, SA
Sobrinho, JSP
Villa, LL
机构
[1] Boldrini Childrens Ctr, Sao Paulo, Brazil
[2] Ludwig Inst Canc Res, Sao Paulo, Brazil
来源
ACTA OPHTHALMOLOGICA SCANDINAVICA | 2003年 / 81卷 / 04期
关键词
retinoblastoma; human papillomavirus; HPV detection; eye; polymerase chain reaction;
D O I
10.1034/j.1600-0420.2003.00112.x
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Purpose: To investigate the presence of human papillomavirus (HPV) DNA in tumour tissue from patients with unilateral retinoblastoma. Methods: Samples of paraffin-embedded tumour tissue from 43 children with unilateral retinoblastoma were collected to investigate the presence of HPV DNA using polymerase chain reaction (PCR) and dot blot hybridization. Results: Oncogenic HPV DNA types 16 and 35 were detected in 12 (27.9%) of 43 tumour specimens. A higher frequency of differentiated tumours (63.3%) was observed among the HPV-positive tumours. Conclusions: Future studies are necessary to demonstrate an association between HPV and sporadic retinoblastoma.
引用
收藏
页码:396 / 398
页数:3
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