Allylic amination via decarboxylative C-N bond formation

被引：38
|
作者：
Mellegaard-Waetzig, SR [1 ]
Rayabarapu, DK [1 ]
Tunge, JA [1 ]
机构：
[1] Univ Kansas, Dept Chem, Lawrence, KS 66045 USA
来源：
SYNLETT | 2005年 / 18期
关键词：
palladium-catalyzed; decarboxylation; allylic amination;
D O I：
10.1055/s-2005-918949
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
This manuscript details the development of a palladium-catalyzed allylic amination that proceeds via decarboxylation of allylic carbamates. Both saturated and aromatic heterocycles undergo decarboxylative rearrangement in good yields. The mechanism of allylation of heteroaromatic amines involves the formation of pi-allyl palladium complexes followed by decarboxylation of the carbamate. Finally, the heteroaromatic anion equivalent is allylated to provide allylic amines.
引用
收藏
页码：2759 / 2762
页数：4
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