Carbon nanotubes for transdermal drug delivery

被引：48
|
作者：
Degim, Ismail Tuncer [1 ,2 ]
Burgess, Diane J. [2 ]
Papadimitrakopoulos, Fotios [3 ]
机构：
[1] Gazi Univ, Dept Pharmaceut Technol, Fac Pharm, TR-06330 Ankara, Turkey
[2] Univ Connecticut, Sch Pharm, Storrs, CT 06269 USA
[3] Univ Connecticut, Inst Mat Sci, Storrs, CT 06269 USA
来源：
JOURNAL OF MICROENCAPSULATION | 2010年 / 27卷 / 08期
关键词：
INDOMETHACIN; WATER; CELLS; SOLUBILIZATION; IONTOPHORESIS; PERMEABILITY; TRANSPORTERS; DOXORUBICIN; ABSORPTION; BEHAVIOR;
D O I：
10.3109/02652048.2010.506581
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
In this study, drug carrier properties through skin and penetration enhancement effects of carbon nanotubes (CNTs) are presented. Multi-walled and double-walled carbon nanotubes were used. Penetration enhancement into the skin following passive diffusion and iontophoresis were determined. Possible solubility enhancement effects and drug adsorption properties of CNTs were investigated. CNTs were found to be a useful drug carrier system and they can provide a high loading and enhanced transdermal penetration for especially hydrophobic drugs. The electroconductive nature of CNTs allows easy application of iontophoresis and the additional advantage of CNTs appears to be using them as electrodes.</.
引用
收藏
页码：669 / 681
页数：13
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