Solid-phase synthesis of dibenzoxazepinones

被引：15

作者：

Hone, ND ^{[1
]}

Salter, JI ^{[1
]}

Reader, JC ^{[1
]}

机构：

[1] Millennium Pharmaceut Ltd, Cambridge CB1 6ET, England

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 44期

关键词：

D O I：

10.1016/j.tetlet.2003.09.037

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two novel solid-phase routes to the pharmaceutically relevant dibenzoxazepinone nucleus are described. In one, a key cyclisation step involves intramolecular phenolate displacement of an activated aryl fluoride. In the second, the tricyclic nucleus is prepared in solution prior to derivatisation on resin. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：8169 / 8172

页数：4

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