Effectiveness of COVID-19 Convalescent Plasma Infusion Within 48 Hours of Hospitalization With SARS-CoV-2 Infection

被引：1

作者：

Lattanzio, Natalia ^{[1
]}

Acosta-Diaz, Cristina ^{[1
]}

Villasmil, Ricardo J. ^{[1
]}

Kirkland, Zachary ^{[1
]}

Bass, Caitlin ^{[2
]}

Yenari, Sage ^{[3
]}

Conte, Jorge ^{[1
]}

Dawkins, Kevin ^{[1
]}

Fonseca, Tamela ^{[4
]}

Grimes, Cindy ^{[3
]}

Stewart, Angie ^{[5
]}

Geary, Mary E. ^{[6
]}

Vore, Harold ^{[7
]}

Hamad, Karen ^{[1
]}

Wiese-Rometsch, Wilhelmine ^{[1
]}

Fiorica, James ^{[8
]}

Gordillo, Manuel ^{[9
]}

Mercado, Roberto ^{[9
]}

Voelker, Kirk ^{[10
]}

机构：

[1] Florida State Univ, Coll Med, Sarasota Mem Hosp, Internal Med, Sarasota, FL 34233 USA

[2] Sarasota Mem Hosp, Internal Med, Sarasota, FL USA

[3] Sarasota Mem Hosp, Med, Sarasota, FL USA

[4] Sarasota Mem Hosp, Clin Res, Sarasota, FL USA

[5] Sarasota Mem Hosp, Clin Database Adm, Sarasota, FL USA

[6] Sarasota Mem Hosp, Qual Improvement, Sarasota, FL USA

[7] Sarasota Mem Hosp, Pathol, Sarasota, FL USA

[8] Sarasota Mem Hosp, Oncol, Sarasota, FL USA

[9] Sarasota Mem Hosp, Infect Dis, Sarasota, FL USA

[10] Sarasota Mem Hosp, Pulmonol & Crit Care, Sarasota, FL USA

来源：

CUREUS JOURNAL OF MEDICAL SCIENCE | 2021年 / 13卷 / 07期

关键词：

covid-19; convalescent plasma; sars-cov-2; discharge to home; infusion;

D O I：

10.7759/cureus.16746

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

On January 30, 2020, the World Health Organization (WHO) declared the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic a worldwide emergency. Worldwide there have been 170 million cases of the resulting disease coronavirus 2019 (COVID-19), of those, 3.53 million have resulted in death. The Food and Drug Administration (FDA) with Mayo Clinic as the lead institution authorized COVID-19 convalescent plasma (CCP) for treatment of SARS-CoV-2 infection. Effective therapeutic window for CCP administration had yet to be defined. We addressed this gap by characterizing longitudinal biologic response and clinical outcomes of COVID-19 patients treated with CCP. Primary outcome was discharged to home/home health.

引用

页数：8

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