Mesenchymal Stem Cells: Potential Therapeutic Prospect of Paracrine Pathways in Neonatal Infection

被引：4

作者：

Miao, Jiayu ^{[1
]}

Ren, Zhuxiao ^{[2
]}

Zhong, Zhicheng ^{[3
]}

Yan, Longli ^{[2
]}

Xia, Xin ^{[2
]}

Wang, Jianlan ^{[2
]}

Yang, Jie ^{[2
]}

机构：

[1] Guangzhou Med Univ, Guangdong Women & Children Hosp, Dept Pediat, Guangzhou, Peoples R China

[2] Guangzhou Med Univ, Guangdong Women & Children Hosp, Dept Neonatol, Xingnan Rd 521-523, Guangzhou 511400, Peoples R China

[3] Guangzhou Med Univ, Guangdong Women & Children Hosp, Prenatal Diag Ctr, Guangzhou, Peoples R China

来源：

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH | 2021年 / 41卷 / 10期

基金：

中国国家自然科学基金;

关键词：

mesenchymal stem cells; paracrine pathways; neonatal infection; CORD BLOOD-CELLS; INJURY; LUNG; TRANSPLANTATION; SECRETION;

D O I：

10.1089/jir.2021.0094

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Infection is the leading cause of admission and mortality in neonatal intensive care units. Immature immune function and antibiotic resistance make the treatment more difficult. However, there is no effective prevention for it. Recently, more and more researches are focusing on stem cell therapy, especially mesenchymal stem cells (MSCs); their potential paracrine effect confer MSCs with a major advantage to treat the immune and inflammatory disorders associated with neonatal infection. In this review, we summarize the basal properties and preclinical evidence of MSCs and explore the potential mechanisms of paracrine factors of MSCs for neonatal infection.

引用

页码：365 / 374

页数：10

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