VEGF receptor Flk-1 plays an important role in c-kit expression in adipose tissue derived stem cells

被引：27

作者：

Bai, Xiaowen ^{[1
]}

Sadat, Sanga ^{[1
]}

Gehmert, Sebastian ^{[1
]}

Alt, Eckhard ^{[1
]}

Song, Yao-Hua ^{[1
]}

机构：

[1] Univ Texas, MD Anderson Canc Ctr, Dept Mol Pathol, Houston, TX 77054 USA

来源：

FEBS LETTERS | 2007年 / 581卷 / 24期

关键词：

stem cell; c-kit; infarction;

D O I：

10.1016/j.febslet.2007.08.063

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It is known that c-kit(+) cells are increased in heart after infarction. The exact origins of the cardiac c-kit+ cells remain to be determined. We asked whether adipose tissue could be a potential source of c-kit+ cells. Our data show that the number of c-kit(+) cells increased in adipose tissue derived stem cells when cultured with conditioned medium from neonatal cardiomyocytes grown under serum deprivation and hypoxia condition. We also found that VEGF receptor Flk-1 is involved in c-kit up regulation via ERK-mediated pathway. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：4681 / 4684

页数：4

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