Adequate lymph node examination is essential to ensure the prognostic value of the lymph node ratio in patients with stage III colorectal cancer

被引:21
|
作者
Shimomura, Manabu [1 ]
Ikeda, Satoshi [2 ]
Takakura, Yuji [1 ]
Kawaguchi, Yasuo [1 ]
Tokunaga, Masakazu [1 ]
Egi, Hiroyuki [2 ]
Hinoi, Takao [2 ]
Okajima, Masazumi [2 ]
Ohdan, Hideki [1 ]
机构
[1] Hiroshima Univ, Dept Surg, Div Frontier Med Sci, Grad Sch Biomed Sci,Programs Biomed Res,Minami Ku, Hiroshima 7348551, Japan
[2] Hiroshima Univ, Dept Endoscop Surg & Surg Sci, Hiroshima 7348551, Japan
关键词
Colorectal cancer; Lymph node ratio; Lymph node examination; TNM 7th edition; COLON-CANCER; SURVIVAL; FLUOROURACIL; CHEMOTHERAPY; OXALIPLATIN; LEUCOVORIN; NUMBER; IMPACT;
D O I
10.1007/s00595-010-4446-2
中图分类号
R61 [外科手术学];
学科分类号
摘要
Purpose. This study aimed to assess the prognostic value of the lymph node ratio (LNR), estimated by dividing the number of positive lymph nodes (LNs) by the number of LNs examined, for stage III colorectal cancer in comparison to the new tumor, nodes, and metastasis (TNM) system, and to evaluate the relationship between the number of LNs examined and the prognostic value of the LNR. Methods. We retrospectively reviewed the clinicopathological data of a cohort of 266 patients with stage III colorectal cancer. We assessed the impact of LNR on the prediction of cancer recurrence in comparison to the TNM system, as well as the prognostic value of LNR in patients with a low LN count. Results. In multivariate analysis, the LNR was found to be an independent risk factor of cancer recurrence. The application of the LNR, in addition to the new TNM system, was more predictive of survival than the TNM system alone. A prognostic separation by LNR was observed in patients who had an adequate number of LNs examined, but not in patients with a low LN count. Conclusions. A stronger prognostic separation can be obtained by using the LNR together with the new TNM system. Adequate lymph node examination is important to ensure the prognostic value of LNR in patients with stage III colorectal cancer.
引用
收藏
页码:1370 / 1379
页数:10
相关论文
共 50 条
  • [1] Adequate lymph node examination is essential to ensure the prognostic value of the lymph node ratio in patients with stage III colorectal cancer
    Manabu Shimomura
    Satoshi Ikeda
    Yuji Takakura
    Yasuo Kawaguchi
    Masakazu Tokunaga
    Hiroyuki Egi
    Takao Hinoi
    Masazumi Okajima
    Hideki Ohdan
    [J]. Surgery Today, 2011, 41 : 1370 - 1379
  • [2] Prognostic value of lymph node ratio in stage III colorectal cancer
    Wong, K. P.
    Poon, J. T. C.
    Fan, J. K. M.
    Law, W. L.
    [J]. COLORECTAL DISEASE, 2011, 13 (10) : 1116 - 1122
  • [3] Prognostic value of the lymph node ratio in stage In colorectal cancer
    Ren, Jing-Qing
    Liu, Jian-Wei
    Chen, Zhi-Tang
    Liu, Shao-Jie
    Huang, Shi-Jie
    Huang, Yong
    Hong, Jing-Song
    [J]. CHINESE JOURNAL OF CANCER, 2012, 31 (05) : 241 - 247
  • [4] Prognostic value of the lymph node ratio in stage Ⅲ colorectal cancer
    Jing-Qing Ren
    [J]. 癌症, 2012, 31 (05) : 241 - 247
  • [5] LYMPH NODE RATIO AS PROGNOSTIC FACTOR IN STAGE III COLORECTAL CANCER PATIENTS
    Elias, Elias
    Faraj, Walid
    Khalifeh, Mohammad
    El Oubeidi, Mohammad
    Hattoum, Hasan
    Melki, Christiane
    Dimassi, Hani
    Shamseddine, Ali
    [J]. ANNALS OF ONCOLOGY, 2011, 22 : v110 - v110
  • [6] Prognostic Value of the Lymph Node Ratio in Stage III Colorectal Cancer: A Systematic Review
    Ceelen, W.
    Van Nieuwenhove, Y.
    Pattyn, P.
    [J]. ANNALS OF SURGICAL ONCOLOGY, 2010, 17 (11) : 2847 - 2855
  • [7] Prognostic Value of the Lymph Node Ratio in Stage III Colorectal Cancer: A Systematic Review
    W. Ceelen
    Y. Van Nieuwenhove
    P. Pattyn
    [J]. Annals of Surgical Oncology, 2010, 17 : 2847 - 2855
  • [8] Prognostic Value of Lymph Node Ratio for Colorectal Cancer
    Ozdemir, Yavuz
    Ozdemir, Sevim
    Filiz, Ali Ilker
    Sucullu, Ilker
    Kurt, Yavuz
    Yildiz, Mehmet
    [J]. BALKAN MEDICAL JOURNAL, 2011, 28 (01) : 86 - 90
  • [9] PROGNOSTIC VALUE OF LYMPH NODE RATIO (LNR) IN STAGE III COLORECTAL CARCINOMA.
    Wong, K.
    Law, W.
    Poon, J.
    Fan, J.
    Lo, O.
    Choi, H.
    [J]. DISEASES OF THE COLON & RECTUM, 2010, 53 (04) : 633 - 633
  • [10] Prognostic value of the lymph node ratio in surgically treated stage III colorectal cancer patients with high numbers of harvested lymph nodes
    Eren, Tunc
    Tigrel, Leyla Zeynep
    Gapbarov, Aman
    Aydemir, Muhammet Ali
    Seneldir, Hatice
    Ekinci, Ozgur
    Alimoglu, Orhan
    [J]. ACTA CHIRURGICA BELGICA, 2023, 123 (05) : 535 - 543