Deep Survival Machines: Fully Parametric Survival Regression and Representation Learning for Censored Data With Competing Risks

被引:61
|
作者
Nagpal, Chirag [1 ]
Li, Xinyu [1 ]
Dubrawski, Artur [1 ]
机构
[1] Carnegie Mellon Univ, Sch Comp Sci, Auton Lab, Pittsburgh, PA 15217 USA
关键词
Hazards; Predictive models; Solid modeling; Bioinformatics; Adaptation models; Analytical models; Optimization; Survival analysis; deep learning; graphical models; censored regression; mixture of experts; MODEL;
D O I
10.1109/JBHI.2021.3052441
中图分类号
TP [自动化技术、计算机技术];
学科分类号
0812 ;
摘要
We describe a new approach to estimating relative risks in time-to-event prediction problems with censored data in a fully parametric manner. Our approach does not require making strong assumptions of constant proportional hazards of the underlying survival distribution, as required by the Cox-proportional hazard model. By jointly learning deep nonlinear representations of the input covariates, we demonstrate the benefits of our approach when used to estimate survival risks through extensive experimentation on multiple real world datasets with different levels of censoring. We further demonstrate advantages of our model in the competing risks scenario. To the best of our knowledge, this is the first work involving fully parametric estimation of survival times with competing risks in the presence of censoring.
引用
收藏
页码:3163 / 3175
页数:13
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