Biocatalytic route for the synthesis of active pharmaceutical diol: A greener approach

被引：0
|
作者：
Meena, Vachan Singh [1 ]
Banerjee, U. C. [1 ]
机构：
[1] Natl Inst Pharmaceut Educ & Res, Dept Pharmaceut Technol Biotechnol, Sect 67, Sas Nagar 160062, Mohali, India
来源：
INDIAN JOURNAL OF BIOTECHNOLOGY | 2011年 / 10卷 / 04期
关键词：
Biocatalysis; biotransformation; Candida viswanathii; epoxide hydrolase; phenyl glycidyl ether; 3-phenoxy-1,2-propane diols; EPOXIDE HYDROLASES; MICROBIOLOGICAL TRANSFORMATIONS; BIOTRANSFORMATIONS; ENHANCEMENT; RESOLUTION; EFFICIENT; OXIDES; ETHER; TOOLS;
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Candida viswanathii was employed for the synthesis of an active pharmaceutical diol from epoxide. Studies on the culture conditions for the production of epoxide hydrolase by C. viswanathii revealed that cultivation temperature of 30 C and medium pH 7 enhanced the enzyme production. The reaction conditions for the epoxide hydrolysis were optimized and the optimal temperature and pH were found to be 30 C and 8, respectively. The optimized reaction time and mixing rate were 15 h and 200 rpm, respectively. Ethanol was found to be a good co-solvent. More than 90% conversion was obtained with these optimized conditions. The product formation progress was monitored by HPLC; the product was characterized by NMR and MASS spectroscopy.
引用
收藏
页码：452 / 457
页数：6
相关论文
共 50 条
  • [1] Cold Active Lipases: Biocatalytic Tools for Greener Technology
    Mhetras, Nutan
    Mapare, Vidhyashri
    Gokhale, Digambar
    [J]. APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 2021, 193 (07) : 2245 - 2266
  • [2] Cold Active Lipases: Biocatalytic Tools for Greener Technology
    Nutan Mhetras
    Vidhyashri Mapare
    Digambar Gokhale
    [J]. Applied Biochemistry and Biotechnology, 2021, 193 : 2245 - 2266
  • [3] Greener approach toward one pot route to pyrazine synthesis
    Ghosh, Pranab
    Mandal, Amitava
    [J]. GREEN CHEMISTRY LETTERS AND REVIEWS, 2012, 5 (02) : 127 - 134
  • [4] Biocatalytic synthesis of chiral pharmaceutical intermediates
    Patel, RN
    [J]. FOOD TECHNOLOGY AND BIOTECHNOLOGY, 2004, 42 (04) : 305 - 325
  • [5] Advances in biocatalytic synthesis of pharmaceutical intermediates
    Panke, S
    Wubbolts, M
    [J]. CURRENT OPINION IN CHEMICAL BIOLOGY, 2005, 9 (02) : 188 - 194
  • [6] A greener route to photoelectrochemically active PbS nanoparticles
    Akhtar, Javeed
    Malik, M. Azad
    O'Brien, Paul
    Wijayantha, K. G. U.
    Dharmadasa, R.
    Hardman, Samantha J. O.
    Graham, Darren M.
    Spencer, Ben F.
    Stubbs, Stuart K.
    Flavell, Wendy R.
    Binks, David J.
    Sirotti, Fausto
    El Kazzi, Mario
    Silly, Mathieu
    [J]. JOURNAL OF MATERIALS CHEMISTRY, 2010, 20 (12) : 2336 - 2344
  • [7] Biocatalytic synthesis of some chiral pharmaceutical intermediates by lipases
    Patel, RN
    Banerjee, A
    Szarka, LJ
    [J]. JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY, 1996, 73 (11) : 1363 - 1375
  • [8] On the development of new biocatalytic processes for practical pharmaceutical synthesis
    Huisman, Gjalt W.
    Collier, Steven J.
    [J]. CURRENT OPINION IN CHEMICAL BIOLOGY, 2013, 17 (02) : 284 - 292
  • [9] Biocatalytic approach for the synthesis of chiral alcohols for the development of pharmaceutical intermediates and other industrial applications: A review
    Naim, Mohd
    Mohammat, Mohd Fazli
    Ariff, Putri Nur Arina Mohd
    Uzir, Mohamad Hekarl
    [J]. ENZYME AND MICROBIAL TECHNOLOGY, 2024, 180
  • [10] Biocatalytic Heterogeneous Processes of Low-Temperature Synthesis of Diol Monoesters
    Kovalenko, G. A.
    Perminova, L., V
    Shashkov, M., V
    Beklemishev, A. B.
    [J]. KINETICS AND CATALYSIS, 2022, 63 (02) : 188 - 196
12345