Trans-synaptic mechanisms orchestrated by mammalian synaptic cell adhesion molecules

被引：5
|
作者：
Kim, Jinhu [1 ,2 ]
Wulschner, Luis E. Gomez [3 ]
Oh, Won Chan [3 ]
Ko, Jaewon [1 ,2 ]
机构：
[1] Daegu Gyeongbuk Inst Sci & Technol DGIST, Dept Brain Sci, 333 Techno Jungangdae Ro, Daegu 42988, South Korea
[2] DGIST, Ctr Synapse Divers & Specific, Daegu, South Korea
[3] Univ Colorado, Sch Med, Dept Pharmacol, Aurora, CO USA
来源：
BIOESSAYS | 2022年 / 44卷 / 11期
基金：
美国国家卫生研究院; 新加坡国家研究基金会;
关键词：
amyloid precursor protein; latrophilin; LRRTM; MDGA; neurexin; synaptic adhesion; transsynaptic signaling; AMYLOID PRECURSOR PROTEIN; STRUCTURAL BASIS; LAR-RPTPS; RELEASE PROBABILITY; HIPPOCAMPAL; SPECIFICITY; NEUREXINS; TRANSMISSION; INHIBITION; ORGANIZERS;
D O I：
10.1002/bies.202200134
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Bidirectional trans-synaptic signaling is essential for the formation, maturation, and plasticity of synaptic connections. Synaptic cell adhesion molecules (CAMs) are prime drivers in shaping the identities of trans-synaptic signaling pathways. A series of recent studies provide evidence that diverse presynaptic cell adhesion proteins dictate the regulation of specific synaptic properties in postsynaptic neurons. Focusing on mammalian synaptic CAMs, this article outlines several exemplary cases supporting this notion and highlights how these trans-synaptic signaling pathways collectively contribute to the specificity and diversity of neural circuit architecture.
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页数：11
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