Increased memory Th17 cells in patients with neuromyelitis optica and multiple sclerosis

被引：85
|
作者：
Li, Ying [1 ]
Wang, Honghao [1 ]
Long, Youming [1 ]
Lu, Zhengqi [1 ]
Hu, Xueqiang [1 ]
机构：
[1] Sun Yat Sen Univ, MS Clin Res Ctr, Dept Neurol, Affiliated Hosp 3, Guangzhou 510630, Guangdong, Peoples R China
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2011年 / 234卷 / 1-2期
关键词：
Th17; Immunological memory; Neuromyelitis optica; Multiple sclerosis; Glucocorticoids; DIAGNOSTIC-CRITERIA; T-CELLS; METHYLPREDNISOLONE;
D O I：
10.1016/j.jneuroim.2011.03.009
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Object: To investigate the clinical relevance of memory Th17 cells in patients with neuromyelitis optica (NMO) or multiple sclerosis (MS). Patients and methods: The proportion of peripheral memory Th17 cells was determined by flow cytometry. Sera IL-17A and IL-23 levels were detected by ELISA kits. Results: Memory Th17 proportion and IL-17A level were much higher in patients with NMO or MS and were related to clinical features. After high-dose intravenous methylprednisolone (IVMP) therapy, memory Th17 proportion and IL-17A and IL-23 levels were decreased. Conclusions: Memory Th17 is related to the development and relapse of NMO and MS, and IVMP can inhibit memory Th17. (C) 2011 Elsevier B.V. All rights reserved.
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页码：155 / 160
页数：6
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