Development and validation of an LC-MS-MS method for the determination of terfenadine in human plasma

被引：17
|
作者：
Xu, A
Linderholm, K
Peng, L
Hulse, J
机构：
[1] Harris Laboratories, Lincoln, NE 68501
来源：
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1996年 / 14卷 / 12期
关键词：
LC-MS-MS; terfenadine; antihistamine;
D O I：
10.1016/0731-7085(96)01804-3
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A sensitive LC-MS-MS method capable of quantifying terfenadine at levels down to 100 pg ml(-1) in human plasma is reported. The method was validated over a linear range from 0.1 to 5.0 ng ml(-1) using a liquid-liquid extraction with a deuterium-labelled internal standard. The between-run precision and accuracy of the calibration standards were 2.6-6.0% RSD and -2.0 to +2.2%, relative error (RE). The between-run and within-run precision and accuracy of quality control samples (0.3, 1.5 and 3.5 ng ml(-1)) were 1.0-5.9% RSD and +1.7 to +6.3% RE. This method was applied to the analysis of human plasma samples.
引用
收藏
页码：1675 / 1680
页数：6
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