Statin use and risk of nonmelanoma skin cancer: a nationwide study in Denmark

被引：12
|
作者：
Arnspang, S. [1 ]
Pottegard, A. [1 ,2 ]
Friis, S. [3 ,4 ,5 ]
Clemmensen, O. [6 ]
Andersen, K. E. [7 ,8 ]
Hallas, J. [1 ,2 ]
Gaist, D. [9 ]
机构：
[1] Univ Southern Denmark, Inst Publ Hlth, DK-5000 Odense C, Denmark
[2] Odense Univ Hosp, Dept Clin Chem & Pharmacol, DK-5000 Odense C, Denmark
[3] Danish Canc Soc Res Ctr, DK-2100 Copenhagen O, Denmark
[4] Aarhus Univ, Fac Hlth, Inst Clin Med, Aarhus, Denmark
[5] Univ Copenhagen, Dept Publ Hlth, Copenhagen, Denmark
[6] Odense Univ Hosp, Dept Clin Pathol, DK-5000 Odense C, Denmark
[7] Univ Southern Denmark, Odense Univ Hosp, Inst Clin Res, Dept Dermatol,Fac Hlth Sci, DK-5000 Odense C, Denmark
[8] Univ Southern Denmark, Odense Univ Hosp, Inst Clin Res, Allergy Ctr,Fac Hlth Sci, DK-5000 Odense C, Denmark
[9] Univ Southern Denmark, Odense Univ Hosp, Inst Clin Res, Dept Neurol,Fac Hlth Sci, DK-5000 Odense C, Denmark
来源：
BRITISH JOURNAL OF CANCER | 2015年 / 112卷 / 01期
关键词：
skin cancer; nonmelanoma; statins; risk; epidemiology; Denmark; SQUAMOUS-CELL CARCINOMA; METAANALYSIS;
D O I：
10.1038/bjc.2014.527
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background: Evidence is conflicting regarding statin use and risk of basal cell (BCC) and squamous cell skin cancer (SCC). Methods: Using Danish nationwide registries, we identified all patients with incident BCC/SCC during 2005-2009 and matched them to population controls. We computed odds ratios (ORs) for BCC and SCC associated with statin use. Results: We identified 38 484 cases of BCC and 3724 cases of SCC. Statin ever use was associated with ORs of 1.09 (CI: 1.06-1.13) for BCC and 1.01 (CI: 0.91-1.11) for SCC. Conclusions: Statin use was not associated with risk of SCC. Residual confounding plausibly explains the marginally increased risk of BCC.
引用
收藏
页码：153 / 156
页数：4
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