Synthesis of adducts of o-quinone metabolites of carcinogenic polycyclic aromatic hydrocarbons with 2′-deoxyribonucleosides

被引：30
|
作者：
Dai, Q [1 ]
Ran, CZ [1 ]
Harvey, RG [1 ]
机构：
[1] Univ Chicago, Ben May Inst Canc Res, Chicago, IL 60637 USA
来源：
ORGANIC LETTERS | 2005年 / 7卷 / 06期
关键词：
D O I：
10.1021/ol0475358
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The first syntheses of the adducts formed in the reactions of o-quinone metabolites of carcinogenic polycyclic aromatic hydrocarbons (BPQ and BAQ) at 2'-deoxyadenosine and 2'-deoxyguanosine sites in DNA are reported. These syntheses entail Pd-catalyzed coupling of protected amine derivatives of catechols with suitably protected halopurine analogues of 2'-deoxyribonucleosides.
引用
收藏
页码：999 / 1002
页数：4
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