Breast conservative surgery for well-differentiated ductal intraepithelial neoplasia: Risk factors for ipsilateral breast tumor recurrence

被引：8

作者：

Toesca, Antonio ^{[1
]}

Botteri, Edoardo ^{[2
,3
]}

Lazzeroni, Matteo ^{[4
]}

Vila, Jose ^{[1
]}

Manika, Aikaterini ^{[1
]}

Ballardini, Bettina ^{[1
]}

Bettarini, Francesca ^{[1
]}

Guerrieri-Gonzaga, Aliana ^{[4
]}

Bonanni, Bernardo ^{[4
]}

Rotmensz, Nicole ^{[2
]}

Viale, Giuseppe ^{[5
]}

Veronesi, Paolo ^{[1
]}

Luini, Alberto ^{[1
]}

Veronesi, Umberto ^{[6
]}

Gentilini, Oreste ^{[1
]}

机构：

[1] European Inst Oncol, Div Breast Surg, I-20141 Milan, Italy

[2] European Inst Oncol, Div Epidemiol & Biostat, I-20141 Milan, Italy

[3] Univ Milan, Dept Occupat Hlth, Milan, Italy

[4] European Inst Oncol, Div Canc Prevent & Genet, I-20141 Milan, Italy

[5] European Inst Oncol, Div Pathol, I-20141 Milan, Italy

[6] European Inst Oncol, Sci Directorate, I-20141 Milan, Italy

来源：

BREAST | 2014年 / 23卷 / 06期

关键词：

Ductal carcinoma in situ; Breast cancer; DCIS; DIN; Radiation therapy; CARCINOMA-IN-SITU; LOW-DOSE TAMOXIFEN; LOCAL RECURRENCE; CANCER; THERAPY; WOMEN; TRIAL; PREDICTORS; EXPRESSION;

D O I：

10.1016/j.breast.2014.08.016

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Rational: We retrospectively analyzed 232 patients affected by well differentiated ductal intraepithelial neoplasia (DIN1c or DCIS G1) treated with conservative surgery without adjuvant radiotherapy. Results: 25 invasive and 18 non-invasive local recurrences were observed ( median follow-up 80 months; 5-year cumulative incidence: 12.2%). Seven of the 15 young patients (<40 y) developed local recurrence (2 in situ, 5 invasive). Age <50 (HR 1.89, 95% C.I. 1.01-3.45), multifocality (HR 3.21, 95% C.I. 1.46-7.06), Ki-67 > 7% (HR 2.33, 95% C.I. 1.20-4.55) and surgical margins <10 mm (HR 2.00, 95% C.I. 1.06-3.76) were significantly associated with an increased risk of local recurrence. Conclusions: Young age, multifocality and small margins appeared as clear risk factors of local recurrence in DIN1c (DCIS G1) population. The presence of multiple poor prognostic features warrant a thorough discussion regarding local treatment. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：829 / 835

页数：7

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