Effect of rLH Supplementation during Controlled Ovarian Stimulation for IVF: Evidence from a Retrospective Analysis of 1470 Poor/Suboptimal/Normal Responders Receiving Either rFSH plus rLH or rFSH Alone

被引:8
|
作者
Canosa, Stefano [1 ,2 ]
Carosso, Andrea Roberto [1 ]
Mercaldo, Noemi [1 ]
Ruffa, Alessandro [1 ]
Evangelista, Francesca [1 ,2 ]
Bongioanni, Francesca [2 ]
Benedetto, Chiara [1 ]
Revelli, Alberto [3 ]
Gennarelli, Gianluca [1 ]
机构
[1] Univ Turin, St Anna Hosp, Dept Surg Sci, Physiopathol Reprod & IVF Unit,Obstet & Gynecol 1, I-10126 Turin, Italy
[2] GeneraLife IVF, Livet, I-10126 Turin, Italy
[3] Univ Turin, St Anna Hosp, Dept Surg Sci, Obstet & Gynecol 2U, I-10126 Turin, Italy
关键词
recombinant FSH; recombinant LH; in vitro fertilization; IVF outcome; live birth rate; poor responders; suboptimal responders; Bologna criteria; POSEIDON classification; IN-VITRO FERTILIZATION; RECOMBINANT LUTEINIZING-HORMONE; ASSISTED REPRODUCTIVE TECHNOLOGY; PREGNANCY RATES; AGE; LH; IMPLANTATION; CYCLES; CELLS; FOLLICULOGENESIS;
D O I
10.3390/jcm11061575
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We retrospectively studied a real-life population of 1470 women undergoing IVF, with poor/suboptimal/normal ovarian responsiveness to controlled ovarian stimulation (COS), comparing the cumulative live birth rate (cLBR) when COS was performed using rFSH alone or rFSH + rLH in a 2:1 ratio. Overall, we observed significantly higher cLBR in the rFSH alone group than in the rFSH + rLH group (29.3% vs. 22.2%, p < 0.01). However, considering only suboptimal/poor responders (n = 309), we observed comparable cLBR (15.6% vs. 15.2%, p = 0.95) despite the fact that patients receiving rFSH + rLH had significantly higher ages and worse ovarian reserve markers. The equivalent effectiveness of rFSH + rLH and rFSH alone was further confirmed after stratification according to the number of oocytes retrieved: despite basal characteristics were still in favor of rFSH alone group, the cLBR always resulted comparable. Even subdividing patients according to the POSEIDON classification, irrespective of differences in the baseline clinical characteristics in favor of FSH alone group, the cLBR resulted comparable in all subgroups. Despite the retrospective, real-life analysis, our data suggest that rLH supplementation in COS may represent a reasonable option for patients with predictable or unexpected poor/suboptimal ovarian responsiveness to FSH, those matching the Bologna criteria for poor responsiveness, and those included in the POSEIDON classification.
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页数:11
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  • [1] Ovarian Stimulation with rFSH plus rLH vs. rFSH alone in poor/ suboptimal/normal responders undergoing IVF: real life analysis of 1382 patients stratified for the number of retrieved oocytes
    Canosa, S.
    Mercaldo, N.
    Carosso, A. R.
    Evangelista, F.
    Racca, C.
    Ruffa, A.
    Gennarelli, G.
    Revelli, A.
    Benedetto, C.
    [J]. HUMAN REPRODUCTION, 2020, 35 : 1457 - 1457