One-pot synthesis and antimicrobial activity of novel naphthyridine derivatives

被引：0
|
作者：
Zheng, Hui [1 ]
Liu, Juan [1 ]
Zhang, Pengfei [1 ]
机构：
[1] Hangzhou Normal Univ, Coll Mat Chem & Chem Engn, Hangzhou 310036, Zhejiang, Peoples R China
来源：
JOURNAL OF CHEMICAL RESEARCH | 2010年 / 11期
关键词：
naphthyridines; amino acids; antimicrobial activity; antifungal activity; ACID;
D O I：
10.3184/030823410X12890461346708
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A one-pot synthetic route was developed to synthesise novel naphthyridine derivatives from amino acids and a series of new naphthyridines was prepared and characterised by IR, (1)H NMR, MS and elemental analysis. The preliminary bioassay results reveal that they have medium antimicrobial activity against Bacillus subtilis, Staphylococcus aureus, Aspergillus, Escherichia coli and Monilia albican. The compounds containing aliphatic amino acids have greater bioactivity than that of those containing aromatic amino acids against Bacillus subtilis and Staphylococcus aureus.
引用
收藏
页码：658 / 660
页数：3
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