Emerging bronchoscopic treatments for chronic obstructive pulmonary disease

被引:22
|
作者
van Geffen, Wouter H. [1 ,2 ]
Kerstjens, Huib A. M. [2 ]
Slebos, Dirk-Jan [2 ]
机构
[1] Med Ctr Leeuwarden, Dept Resp Med, Henri Dunantweg 2, NL-8934 AD Leeuwarden, Netherlands
[2] Univ Groningen, Univ Med Ctr Groningen, Dept Pulm Dis, Groningen, Netherlands
关键词
Chronic obstructive pulmonary disease (COPD); Hyperinflation; Endobronchial valves (EBV); Endobronchial coils (EBC); Lung volume reduction; Bronchoscopic treatment; LUNG-VOLUME-REDUCTION; RANDOMIZED-TRIAL; ENDOBRONCHIAL VALVES; SEVERE EMPHYSEMA; MEDICAL THERAPY; GAS-EXCHANGE; COPD; MULTICENTER; SURGERY; HYPERINFLATION;
D O I
10.1016/j.pharmthera.2017.05.007
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Chronic obstructive pulmonary disease (COPD) is a progressive lung disease characterized by pathophysiological factors including airflow limitation, hyperinflation and reduced gas exchange. Treatment consists of lifestyle changes, lung rehabilitation and pharmacological therapies such as long acting beta-2-agonists (LABA) and long acting muscarinic antagonists (LAMA). More recently bronchoscopic treatments are emerging for COPD. Among them endobronchial valves (EBV) and endobronchial coils (EBC), next to endobronchial stents, sclerosing agents, targeted lung denervation and liquid nitrogen metered cryospray. In this review we aim to summarize the new emerging bronchoscopic treatments and their effect sizes compared with lung rehabilitation and pharmacological therapies. (C) 2017 The Author(s). Published by Elsevier Inc.
引用
收藏
页码:96 / 101
页数:6
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