Age-related changes in the concentrations of major and trace elements in the brain of rats and mice

被引：58
|
作者：
Takahashi, S [1 ]
Takahashi, I
Sato, H
Kubota, Y
Yoshida, S
Muramatsu, Y
机构：
[1] Natl Inst Radiol Sci, Environm & Toxicol Sci Res Grp, Chiba 260, Japan
[2] Nucl Sci Serv Co Ltd, Tokyo, Japan
来源：
BIOLOGICAL TRACE ELEMENT RESEARCH | 2001年 / 80卷 / 02期
关键词：
major element; trace element; brain; rat; mouse; age;
D O I：
10.1385/BTER:80:2:145
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Age-related changes in the concentrations of constituent elements in the brains of rats and mice 1 wk to 24 mo old were determined with inductively coupled plasma-mass spectrometry (ICP-MS) and inductively coupled plasma-atomic emission spectrometry (ICP-AES). Seventeen elements could be determined with reasonable accuracy and reproducibility. They were P, K, Na, Mg, Ca, Fe, Zn, Cu, Rb, Al, Mn, Sr, Mo, Co, Pb, Cs, and Cd in order of concentrations in the adult rat brains. In these elements, six major elements (P, K, Na, Fe, Mg, Ca) were determined with ICP-AES and the others with ICP-MS. The concentrations of each element and the pattern of age-related changes were similar between the rat and mouse brains. The elements of which concentrations decreased with aging were K and Rb. On the other hand, the concentrations of some metal elements, including Fe, Cu, Sr, and Co, appeared to increase with growth and aging. The concentrations of other elements were relatively constant throughout the age examined.
引用
收藏
页码：145 / 158
页数：14
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