Upfront tandem autologous non-myeloablative allogeneic stem cell transplant in high-risk multiple myeloma: a long-term single-centre experience

被引：1
|
作者：
Nguyen, Phillip C. [1 ]
Muirhead, Jenny [1 ]
Tan, Joanne [1 ]
Kalff, Anna [1 ,2 ]
Bergin, Krystal [1 ,2 ]
Walker, Patricia [1 ]
Spencer, Andrew [1 ,2 ]
机构：
[1] Monash Univ, Alfred Hlth, Dept Clin Haematol, Melbourne, Vic, Australia
[2] Monash Univ, Australian Ctr Blood Dis, Melbourne, Vic, Australia
来源：
INTERNAL MEDICINE JOURNAL | 2022年 / 52卷 / 07期
关键词：
multiple myeloma; transplant; high risk; allogeneic; CYTOGENETICS; CONSENSUS; IFM99-03; STANDARD; OUTCOMES;
D O I：
10.1111/imj.15842
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The role of upfront non-myeloablative allogeneic stem cell transplantation (NMA alloSCT) in high-risk multiple myeloma (HR-MM) is unclear. We evaluated outcomes of NMA alloSCT following autologous stem cell transplant (ASCT) compared with ASCT alone for newly diagnosed HR-MM. Two-year progression-free survival was improved in the ASCT-NMA alloSCT group (44% vs 16%; P = 0.035), with a trend for improved overall survival (P = 0.118). These results suggest that ASCT-NMA alloSCT can be considered as upfront therapy in HR-MM.
引用
收藏
页码：1263 / 1267
页数：5
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