How does PKMζ maintain long-term memory?

被引:271
|
作者
Sacktor, Todd C. [1 ,2 ]
机构
[1] Suny Downstate Med Ctr, Robert F Furchgott Ctr Neural & Behav Sci, Dept Physiol, Brooklyn, NY 11203 USA
[2] Suny Downstate Med Ctr, Robert F Furchgott Ctr Neural & Behav Sci, Dept Pharmacol & Neurol, Brooklyn, NY 11203 USA
基金
美国国家卫生研究院;
关键词
KINASE-M-ZETA; AMPA RECEPTOR TRAFFICKING; LOCAL PROTEIN-SYNTHESIS; MOLECULAR-BIOLOGY; SYNAPTIC-TRANSMISSION; NEURONAL ISOFORM; MESSENGER-RNA; MAINTENANCE; GLUR2; POTENTIATION;
D O I
10.1038/nrn2949
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Most of the molecular mechanisms contributing to long-term memory have been found to consolidate information within a brief time window after learning, but not to maintain information during memory storage. However, with the discovery that synaptic long-term potentiation is maintained by the persistently active protein kinase, protein kinase M zeta (PKM zeta), a possible mechanism of memory storage has been identified. Recent research shows how PKM zeta might perpetuate information both at synapses and during long-term memory.
引用
收藏
页码:9 / 15
页数:7
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