Paternal age and epilepsy in the offspring

被引：58
|
作者：
Vestergaard, M
Mork, A
Madsen, KM
Olsen, J
机构：
[1] Univ Aarhus, Dept Epidemiol, Inst Publ Hlth, Danish epidemiol Sci Ctr, DK-8000 Aarhus, Denmark
[2] Univ Minnesota, Sch Publ Hlth, Div Environm & Occupat Hlth, Minneapolis, MN 55455 USA
[3] Univ Calif Los Angeles, Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA 90095 USA
来源：
EUROPEAN JOURNAL OF EPIDEMIOLOGY | 2005年 / 20卷 / 12期
基金：
英国医学研究理事会;
关键词：
de novo mutations; epidemiology; epilepsy; paternal age;
D O I：
10.1007/s10654-005-4250-2
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Advanced paternal age is associated with a higher rate of de novo mutation in sperm cells and mental disorders in the offspring. In a population based cohort study of 96,654 children, we found that fathers aged 35 years or more were slightly more likely to have a child diagnosed with epilepsy compared to fathers aged 25-29 years. Our data suggest a modest paternal effect on the aetiology of epilepsy.
引用
收藏
页码：1003 / 1005
页数：3
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