Clinical Severity and Rotavirus Vaccination among Children Hospitalized for Acute Gastroenteritis in Belem, Northern Brazil

被引:3
|
作者
Justino, Maria Cleonice A. [1 ]
Brasil, Patricia [2 ]
Abreu, Erika [1 ]
Miranda, Yllen [1 ]
Mascarenhas, Joana D'Arc P. [1 ]
Guerra, Sylvia F. S. [1 ]
Linhares, Alexandre C. [1 ]
机构
[1] Minist Saude, Secretaria Vigilancia Saude, Inst Evandro Chagas, Ananindeua, Para, Brazil
[2] Fundacao Oswaldo Cruz, Inst Pesquisa Clin, BR-21040900 Rio De Janeiro, Brazil
关键词
rotavirus; gastroenteritis; severity; vaccination status; EFFICACY; SAFETY; IMPACT;
D O I
10.1093/tropej/fmv098
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
In March 2006, Brazil introduced the monovalent rotavirus (RV) vaccine (Rotarix (TM)) into the public sector. This study assessed the severity of rotavirus gastroenteritis (RVGE) according to the vaccination status among hospitalized children. We identified 1023 RVGE episodes among not vaccinated (n = 252), partially vaccinated (n = 156) and fully vaccinated (n = 615) children. Very severe gastroenteritis (scored >= 15) was reported in 16.7, 17.9 and 13.5% of not vaccinated, partially vaccinated and fully vaccinated children, respectively. There was a trend for a shorter duration of RV diarrhoea among vaccinated children than in not vaccinated children (p = 0.07). A protective effect of vaccination was noted when mean duration of symptoms and hospital stay are analysed, comparing unvaccinated, partially vaccinated and fully vaccinated children (p < 0.05). We showed a vaccination dose effect trend, with fully vaccinated children having less-severe RVGE than not vaccinated and partially vaccinated children.
引用
收藏
页码:276 / 281
页数:6
相关论文
共 50 条
  • [1] Rotavirus antigenemia as a common event among children hospitalised for severe, acute gastroenteritis in Belem, northern Brazil
    Justino, Maria Cleonice A.
    Campos, Erika A.
    Mascarenhas, Joana D'arc P.
    Soares, Luana S.
    Guerra, Sylvia de Fatima S.
    Furlaneto, Ismari P.
    Pavao, Manoel Jaime C., Jr.
    Maciel, Tassio S.
    Farias, Fredison P.
    Bezerra, Orvacio M.
    Vinente, Caio Breno G.
    Barros, Rodrigo Jose S.
    Linhares, Alexandre C.
    [J]. BMC PEDIATRICS, 2019, 19 (1)
  • [2] Epidemiology and Factors Related to Clinical Severity of Acute Gastroenteritis in Hospitalized Children after the Introduction of Rotavirus Vaccination
    Kim, Ahlee
    Chang, Ju Young
    Shin, Sue
    Yi, Hana
    Moon, Jin Soo
    Ko, Jae Sung
    Oh, Sohee
    [J]. JOURNAL OF KOREAN MEDICAL SCIENCE, 2017, 32 (03) : 465 - 474
  • [3] Phylogenetic analysis of human group C rotavirus in hospitalized children with gastroenteritis in Belem, Brazil
    Lobo, Patricia dos Santos
    dos Santos Guerra, Sylvia de Fatima
    Monteiro Siqueira, Jones Anderson
    Soares, Luana da Silva
    Gabbay, Yvone Benchimol
    Linhares, Alexandre C.
    Pereira Mascarenhas, Joana D'Arc
    [J]. JOURNAL OF MEDICAL VIROLOGY, 2016, 88 (04) : 728 - 733
  • [4] Norovirus infection among children with acute gastroenteritis in Recife, Brazil: disease severity is comparable to rotavirus gastroenteritis
    Nakagomi, T.
    Correia, J. B.
    Nakagomi, O.
    Montenegro, F. M. U.
    Cuevas, L. E.
    Cunliffe, N. A.
    Hart, C. A.
    [J]. ARCHIVES OF VIROLOGY, 2008, 153 (05) : 957 - 960
  • [5] Norovirus infection among children with acute gastroenteritis in Recife, Brazil: disease severity is comparable to rotavirus gastroenteritis
    T. Nakagomi
    J. B. Correia
    O. Nakagomi
    F. M. U. Montenegro
    L. E. Cuevas
    N. A. Cunliffe
    C. A. Hart
    [J]. Archives of Virology, 2008, 153
  • [6] Emergence of G12P[6] rotavirus strains among hospitalised children with acute gastroenteritis in Belem, Northern Brazil, following introduction of a rotavirus vaccine
    Guerra, Sylvia F. S.
    Fecury, Priscylla C. M. S.
    Bezerra, Delana A. M.
    Lobo, Patricia S.
    Penha Junior, Edvaldo T.
    Sousa Junior, Edivaldo C.
    Mascarenhas, Joana D'Arc P.
    Soares, Luana S.
    Justino, Maria Cleonice A.
    Linhares, Alexandre C.
    [J]. ARCHIVES OF VIROLOGY, 2019, 164 (08) : 2107 - 2117
  • [7] Clinical Severity of Gastroenteritis in Children Hospitalized With Rotavirus Infection Before and Post Introduction of a National Rotavirus Vaccination Program in Australia
    Clarke, Michelle
    Liew, Ying Ying
    Mathew, Suja Mary
    Marshall, Helen Siobhan
    [J]. PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2020, 39 (09) : E289 - E290
  • [8] ROTAVIRUS SEROTYPES AND SEVERITY OF ACUTE GASTROENTERITIS IN HOSPITALIZED CHILDREN IN MILAN, ITALY
    Zuccotti, G. V.
    Dilillo, D.
    Romano, L.
    Meneghin, F.
    Bottone, R.
    Giachino, R.
    Besana, R.
    Ricciardi, G.
    Sterpa, A.
    Montrasio, G.
    Zanetti, A.
    [J]. ACTA PAEDIATRICA, 2009, 98 : 276 - 276
  • [9] ACUTE DIARRHEA ASSOCIATED WITH ROTAVIRUS AMONG CHILDREN LIVING IN BELEM, BRAZIL
    LINHARES, AC
    MONCAO, HC
    GABBAY, YB
    DEARAUJO, VLC
    SERRUYA, AC
    LOUREIRO, ECB
    [J]. TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1983, 77 (03) : 384 - 390
  • [10] Norovirus infection in children admitted to hospital for acute gastroenteritis in Belem, Para, Northern Brazil
    Monteiro Siqueira, Jones Anderson
    Linhares, Alexandre da Costa
    Nascimento de Carvalho, Thais Cristina
    Aragao, Glicelia Cruz
    Oliveira, Darleise de Souza
    dos Santos, Mirleide Cordeiro
    de Sousa, Maisa Silva
    Aguiar Justino, Maria Cleonice
    Pereira Mascarenhas, Joana D'Arc
    Gabbay, Yvone Benchimol
    [J]. JOURNAL OF MEDICAL VIROLOGY, 2013, 85 (04) : 737 - 744