Endovascular treatment for acute basilar artery occlusion: A multicenter randomized controlled trial (ATTENTION)

被引：56

作者：

Tao, Chunrong ^{[1
,2
]}

Li, Rui ^{[1
,2
]}

Zhu, Yuyou ^{[1
,2
]}

Qun, Sen ^{[1
,2
]}

Xu, Pengfei ^{[1
,2
]}

Wang, Li ^{[1
,2
]}

Zhang, Chao ^{[1
,2
]}

Liu, Tianlong ^{[1
,2
]}

Song, Jianlong ^{[1
,2
]}

Sun, Wen ^{[1
,2
]}

Wang, Guoping ^{[1
,2
]}

Baxter, Blaise ^{[3
]}

Qureshi, Adnan ^{[4
]}

Liu, Xinfeng ^{[1
,2
,5
]}

Nogueira, Raul G. ^{[6
,7
]}

Hu, Wei ^{[1
,2
]}

机构：

[1] Univ Sci & Technol China, Affiliated Hosp USTC 1, Stroke Ctr, Hefei 230001, Anhui, Peoples R China

[2] Univ Sci & Technol China, Affiliated Hosp USTC 1, Dept Neurol, Div Life Sci & Med, Hefei 230001, Anhui, Peoples R China

[3] Lehigh Valley Hlth Network, Allentown, PA USA

[4] Univ Minnesota, Zeenat Qureshi Stroke Res Ctr, Morris, MN 56267 USA

[5] Nanjing Univ, Affiliated Jinling Hosp, Dept Neurol, Med Sch, Nanjing, Peoples R China

[6] Univ Pittsburgh, Dept Neurol, UPMC Stroke Inst, 200 Lothrop St,C-400 PUH, Pittsburgh, PA 15213 USA

[7] Univ Pittsburgh, Dept Neurosurg, UPMC Stroke Inst, 200 Lothrop St,C-400 PUH, Pittsburgh, PA 15213 USA

来源：

INTERNATIONAL JOURNAL OF STROKE | 2022年 / 17卷 / 07期

关键词：

Basilar artery occlusion; ischemic stroke; endovascular treatment; randomized trial; ISCHEMIC-STROKE; MEDICAL-TREATMENT; THROMBOLYSIS; THERAPY; THROMBECTOMY;

D O I：

10.1177/17474930221077164

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and hypothesis: Recently, two multicenter randomized controlled trials (RCT) failed to show a significantly beneficial effect of endovascular treatment (EVT) in patients with acute basilar artery occlusion (BAO). However, both trials suffered from equipoise issues which may have hindered the validity of the trial results. Therefore, additional RCT studies are needed to explore the potential benefit of EVT in patients presenting with BAO. Study design: ATTENTION is an investigator-initiated, multicenter, prospective, randomized, controlled clinical trial with open-label treatment and blinded outcome assessment (PROBE) of EVT versus best medical management (BMM). The primary effect parameter is a modified Rankin Score of 0-3 at day 90. Discussion: ATTENTION will provide evidence for the efficacy and safety of EVT in stroke patients within 12 h after BAO.

引用

页码：815 / 819

页数：5

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