Effects of Qingshen Granules on the Oxidative Stress-NF/kB Signal Pathway in Unilateral Ureteral Obstruction Rats

被引:18
|
作者
Jin, Hua [1 ]
Wang, Yiping [1 ]
Wang, Dong [1 ]
Zhang, Lei [1 ]
机构
[1] Anhui Univ Tradit Chinese Med, Affiliated Hosp 1, Dept Nephrol, Hefei 230031, Anhui, Peoples R China
基金
安徽省自然科学基金; 中国国家自然科学基金;
关键词
NF-KAPPA-B; MESENCHYMAL TRANSITION; INTERSTITIAL FIBROSIS; RENAL INJURY; MODEL; HYPERTENSION; INFLAMMATION; MECHANISMS;
D O I
10.1155/2018/4761925
中图分类号
R [医药、卫生];
学科分类号
10 ;
摘要
Background. The activation of NF-kappa B (NF/kB) signaling pathway plays an important role in the process of epithelial-mesenchymal transition (EMT) and renal interstitial fibrosis (RIF) in renal tubules. The process of oxidative stress reaction in kidney is via excessive reactive oxygen species (ROS) production to activate NF/kB signaling pathway. Qingshen Granule (QSG) is an effective Chinese formula utilized to treat chronic renal failure. Previous studies confirmed that QSG could inhibit RIF in unilateral ureteral obstruction (UUO) rats. In this study, we used UUO rats to investigate the effects of QSG on oxidative stress and the activation of NF/kB signaling. Seventy male Sprague-Dawley (SD) rats were randomly divided into a sham group, UUO model group, Qingshen Granules (QSG) high-dose, medium-dose, and low-dose groups, PDTC group, and candesartan group (10 rats in each group). Our study demonstrated that oxidative stress-NF/kB signal pathway contributed to the formation of UUO renal interstitial fibrosis. QSG may protect against RIF by inhibiting the oxidative stress-NF/kB signal pathway, reducing inflammation, and improving renal tubular EMT.
引用
收藏
页数:9
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