Regeneration of the lateral vestibulospinal tract in adult rats by transplants of embryonic brain tissue

被引:2
|
作者
Ito, J [1 ]
Murata, M
Kawaguchi, S
机构
[1] Otsu Red Cross Hosp, Dept Otolaryngol, Otsu, Shiga 5200046, Japan
[2] Kyoto Univ, Grad Sch Med, Dept Integrat Brain Sci, Kyoto 6068501, Japan
关键词
regeneration; lateral vestibulospinal tract; transection; wheat germ agglutinin-conjugated horseradish peroxidase; adult rat; embryo; transplantation;
D O I
10.1016/S0304-3940(98)00897-0
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
We transected the lateral vestibulospinal tract in the spinal cord of adult rats. In one group we performed simple transection, and in other group we transplanted the lesion with embryonic tissue. In rats receiving simple transection, there was no regeneration, but in 22% of the rats receiving transplants of embryonic tissue, the axon regrew beyond the transected site, regenerated on the denervated side, terminating in the normal targets. The present findings are contrary to the widely held view that the adult mammalian central vestibular system cannot be restored following damage. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:67 / 70
页数:4
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