CD34+ Collection Efficiency as a Function of Blood Volumes Processed in Pediatric Autologous Peripheral Blood Stem Cell Collection

被引：16

作者：

Dubrovsky, Leonid ^{[1
]}

Wong, Edward C. C. ^{[2
]}

Perez-Albuerne, Evelio ^{[1
]}

Loechelt, Brett ^{[1
]}

Kamani, Naynesh ^{[1
]}

Sande, Jane ^{[1
]}

Mintz, Kathy ^{[1
,3
]}

Paul, Wendy ^{[2
]}

Luban, Naomi L. C. ^{[2
]}

Rood, Brian R. ^{[4
]}

Fry, Terry ^{[1
]}

机构：

[1] Childrens Natl Med Ctr, Div Bone Marrow Transplantat, Washington, DC 20010 USA

[2] Childrens Natl Med Ctr, Div Lab Med, Ctr Canc & Blood Disorders, Washington, DC 20010 USA

[3] George Washington Univ, Sch Med & Hlth Sci, William & Shirley Howard Stem Cell Proc Lab, Washington, DC 20052 USA

[4] Childrens Natl Med Ctr, Div Oncol, Ctr Canc & Blood Disorders, Washington, DC 20010 USA

来源：

JOURNAL OF CLINICAL APHERESIS | 2011年 / 26卷 / 03期

关键词：

leukapheresis; pediatric; stem cell transplant; HIGH-DOSE CHEMOTHERAPY; SMALL CHILDREN; COBE SPECTRA; TRANSPLANTATION; NEUROBLASTOMA; LEUKAPHERESIS; SYSTEM; TUMORS; EXPERIENCE; RESCUE;

D O I：

10.1002/jca.20281

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose: To characterize the relationship between CD34(+) collection efficiency and blood volumes processed in pediatric patients undergoing autologous peripheral blood stem cell (PBSC) collection. Methods: Retrospective 8-year (2001-2009) study of pediatric patients (n = 79) with neuroblastoma and central nervous system (CNS) tumors undergoing first day of autologous PBSC harvest using MNC program on the COBE Spectra (Caridian BCT, Lakewood, CO) was performed. Patients undergoing 0 to 2.9 BV (standard volume), 3 to 6 BV (large volume), and greater than 6 BV (ultra large volume) harvests were evaluated for CD34(+) collection efficiency, diagnosis (neuroblastoma vs. nonneuroblastoma), disease type (primary vs. relapse), mobilization regimen, granulocyte colony stimulating factor (GCSF) dose, and apheresis complications. Results: CD34(+) collection efficiencies (CE) for neuroblastoma patients were 67%, 50%, and 53% for standard (n = 14), large (n = 9), and ultra large (n = 5) volume harvests, respectively. Similarly, patients with nonneuroblastoma diagnoses had CD34(+) CE of 63%, 55%, and 65% for low (n = 19), large (n = 27), and ultra large (n = 5) volume harvests, respectively. Weight, granulocyte colony stimulating factor (G-CSF) stimulation, type of mobilization, and apheresis complications (normalized by run time) were similar between the standard, large, and ultra large volume groups in patients with either neuroblastoma or nonneuroblastoma diagnoses. Conclusions: CD34(+) collection efficiency in pediatric autologous PBSC collection on the first day of harvest does not decrease with higher numbers of blood volumes processed in patients with either neuroblastoma or nonneuroblastoma primary disease. These results indirectly indicate bone marrow CD34(+) cell mobilization occurs with longer apheresis procedures in pediatric patients. J. Clin. Apheresis 26:131-137, 2011. (C) 2011 Wiley-Liss, Inc.

引用

页码：131 / 137

页数：7

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