Cytokines as potential therapeutic targets for inflammatory skin diseases

被引:0
|
作者
Numerof, RP
Dinarello, CA
Asadullah, K
机构
[1] Berlex Biosci, RBA Dermatol USA, Richmond, CA 94804 USA
[2] Univ Colorado, Sch Med, Denver, CO USA
[3] Schering AG, CRBA Dermatol, Berlin, Germany
关键词
cytokines; inflammation; psoriasis;
D O I
暂无
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A network of pro-inflammatory cytokines is a central feature in the pathophysiology of cutaneous inflammatory diseases. Thus, the delineation of precise roles for particular cytokines and the development of cytokine-directed therapeutics have become areas of intense investigation. While anti-TNF therapeutics have proven to be effective for the treatment of psoriasis, clinical investigations have now begun with other cytokine-directed therapies, such as those targeting IFN-g, IL-12p4O, and IL-18. In addition to therapeutics that target cytokines directly, strategies that target cytokine signaling pathways are in development too. In this short review, we summarize key findings from a recent workshop on cytokines as potential therapeutic targets for inflammatory skin diseases.
引用
收藏
页码:101 / 103
页数:3
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