Microbial transformation of mestranol by Cunninghamella elegans

被引：11
|
作者：
Choudhary, MI [1 ]
Musharraf, SG [1 ]
Siddiqui, ZA [1 ]
Khan, NT [1 ]
Ali, RA [1 ]
Atta-Ur-Rahman [1 ]
机构：
[1] Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem Sci, Karachi 75270, Pakistan
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2005年 / 53卷 / 08期
关键词：
mestranol; 17; beta-methoxymestranol; microbial transformation; Cunninghamella elegans;
D O I：
10.1248/cpb.53.1011
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The microbial transformation of an oral contraceptive, mestranol (1) by Cunninghamella elegans yielded two hydroxylated metabolites, 6 beta-hydroxymestranol (2) and 6 beta,12 beta-dihydroxymestranol (3). Metabolite 3 was found to be a new compound. These metabolites were structurally characterized on the basis of spectroscopic techniques.
引用
收藏
页码：1011 / 1013
页数：3
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