Multiplexed Neutralizing Antibody Assay Identifies Potential Epitopes on the AAV Capsid

被引:0
|
作者
Schmit, Pauline
Zinn, Eric
Fieldsend, Allegra
Vandenberghe, Luk
机构
[1] Harvard Med Sch, Grousbeck Gene Therapy Ctr, Mass Eye & Ear, Boston, MA 02115 USA
[2] Broad Inst MIT & Harvard, Boston, MA USA
关键词
D O I
暂无
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
1202
引用
收藏
页码:520 / 520
页数:1
相关论文
共 50 条
  • [1] Improvement of a neutralizing antibody assay for AAV capsids
    Watano, R.
    Ohba, K.
    Sehara, Y.
    Saga, Y.
    Urabe, M.
    Mizukami, H.
    HUMAN GENE THERAPY, 2024, 35 (3-4) : A313 - A313
  • [2] Massively Parallel Screening of Barcoded AAV Capsid Variants for Neutralizing Antibody Reactivity
    Rapti, Kleopatra
    Kraemer, Chiara
    Meng, Ning
    Grimm, Dirk
    MOLECULAR THERAPY, 2024, 32 (04) : 465 - 466
  • [3] Massively parallel screening of barcoded AAV capsid variants for neutralizing antibody reactivity
    Rapti, K.
    Kraemer, C.
    Grimm, D.
    HUMAN GENE THERAPY, 2024, 35 (3-4) : A71 - A71
  • [4] Assay Conditions Significantly Alter AAV Neutralizing Antibody Determination
    Turunen, Heikki T.
    Zinn, Eric
    Vandenberghe, Luk H.
    MOLECULAR THERAPY, 2016, 24 : S184 - S185
  • [5] Assay Conditions Significantly Alter AAV Neutralizing Antibody Determination Outcome
    Turunen, H. T.
    Zinn, E.
    Vandenberghe, L. H.
    HUMAN GENE THERAPY, 2015, 26 (10) : A96 - A96
  • [6] Human Polyclonal Anti-AAV Neutralizing Antibody Epitope Mapping by NGS Identifies Common Epitopes and Enables the Design of Stealth Mutants
    Baggett, Helen R.
    Chang, Xiao Lan
    Adachi, Kei
    Nakai, Hiroyuki
    MOLECULAR THERAPY, 2019, 27 (04) : 187 - 187
  • [7] Rapid AAV Neutralizing Antibody Determination with a Cell-Binding Assay
    Zhang, Junping
    Guo, Ping
    Huang, Jianhe
    Chew, Helen
    Firrman, Jenni A.
    Liu, Linshu
    Sang, Niangli
    Diao, Yong
    Xiao, Weidong
    MOLECULAR THERAPY, 2018, 26 (05) : 326 - 326
  • [8] AAV8-mediated gene expression in pigs with neutralizing antibody against vector capsid
    Watano, R.
    Ohmori, T.
    Hishikawa, S.
    Sakata, A.
    Nishimura, S.
    Mizukami, H.
    HUMAN GENE THERAPY, 2018, 29 (12) : A98 - A98
  • [9] Rapid AAV-Neutralizing Antibody Determination with a Cell-Binding Assay
    Guo, Ping
    Zhang, Junping
    Chrzanowski, Matthew
    Huang, Jianhe
    Chew, Helen
    Firrman, Jenni A.
    Sang, Nianli
    Diao, Yong
    Xiao, Weidong
    MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT, 2019, 13 : 40 - 46
  • [10] Intravitreal injection of a rationally designed AAV capsid library in non-human primate identifies variants with enhanced retinal transduction and neutralizing antibody evasion
    Kellish, Patrick C.
    Marsic, Damien
    Crosson, Sean M.
    Choudhury, Shreyasi
    Scalabrino, Miranda L.
    Strang, Christianne E.
    Hill, Julie
    McCullough, K. Tyler
    Peterson, James J.
    Fajardo, Diego
    Gupte, Siddhant
    Makal, Victoria
    Kondratov, Oleksandr
    Kondratova, Liudmyla
    Iyer, Siva
    Witherspoon, C. Douglas
    Gamlin, Paul D.
    Zolotukhin, Sergei
    Boye, Sanford L.
    Boye, Shannon E.
    MOLECULAR THERAPY, 2023, 31 (12) : 3441 - 3456