Sex- and age-dependent effects of early postnatal sibling deprivation on spatial learning and memory in adult rats

被引：5
|
作者：
Li, Yan-Qin [1 ]
Wang, Xiao-yi [1 ]
Zhai, Hai-feng [1 ]
Zhang, Xiang Yang [2 ]
Kosten, Therese [2 ]
Lu, Lin [1 ]
机构：
[1] Peking Univ, Natl Inst Drug Dependence, Beijing 100083, Peoples R China
[2] Baylor Coll Med, Menninger Dept Psychiat & Behav Sci, VA Med Ctr, Houston, TX 77030 USA
来源：
BEHAVIOURAL BRAIN RESEARCH | 2008年 / 186卷 / 01期
基金：
中国国家自然科学基金;
关键词：
early postnatal sibling deprivation; development; spatial learning and memory; sex; age;
D O I：
10.1016/j.bbr.2007.07.028
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
In this study. we investigated the effects of early postnatal sibling deprivation (EPSD) on spatial learning and memory in adult rats. Litters were culled to one pup with its mother on postnatal day (PN) 1 or 7 and their spatial learning and memory ability were examined with Morris water maze in adult. EPSD on PN1 improved, but on PN7 impaired performance of the spatial learning task in adult female rats. However, EPSD did not have any effect on the spatial learning ability in adult male rats. (c) 2007 Elsevier B.V. All rights reserved.
引用
收藏
页码：138 / 142
页数：5
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