Contribution of circulatory cells to asthma exacerbations and lung tissue-resident CD4 T cell memory

被引:6
|
作者
Sethi, Gurupreet S. [1 ]
Gracias, Donald [1 ,3 ]
Croft, Michael [1 ,2 ]
机构
[1] La Jolla Inst Immunol, Ctr Autoimmun & Inflammat, La Jolla, CA 92037 USA
[2] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA
[3] Janssen Pharmaceut Co Johnson & Johnson, Spring House, PA USA
来源
FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷
关键词
asthma; circulatory memory T cells; tissue-resident memory T cells; Trm; FTY720; FINGOLIMOD;
D O I
10.3389/fimmu.2022.951361
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Tissue-resident memory CD4 T cells (Trm) are thought to be a major contributor to asthma relapse, but the role of circulatory T cells in asthma exacerbations or to maintaining the population of lung Trm cells is not fully understood. Here, we used a house dust mite allergen-based murine model of asthma relapse, and monitored the development of lung effector/Trm phenotype CD44(hi)CD62L(lo)CD69(+) CD4 T cells. To determine the contribution of circulatory cells, mice were treated with FTY720, to block lymphocyte egress from lymph nodes. Inhibiting the primary migration of circulatory cells to the lungs mitigated the accumulation and expansion of allergen-driven Trm phenotype cells, but subsequent allergen challenges still resulted in strong lung inflammation and Trm cell accumulation. This was blocked if FTY720 was also given at the time of allergen re-exposure, showing that new circulatory cells contributed to this lung memory/effector T cell pool at times well after the initial sensitization. However, once lung-localized Trm cells developed at high frequency, circulatory cells were not required to maintain this population following allergen re-encounter, even though circulatory cells still were major contributors to the overall asthmatic lung inflammatory response. Our results suggest that strategies that target the response of circulatory memory T cells and Trm cells together might be required to strongly inhibit T cell reactivity to airborne allergens and to limit exacerbations of asthma and their reoccurrence, but the contribution of circulatory T cells might vary in long-term asthmatics possessing a large stable Trm cell population in the lungs.
引用
收藏
页数:12
相关论文
共 50 条
  • [1] Anti-CD3 inhibits circulatory and tissue-resident memory CD4 T cells that drive asthma exacerbations in mice
    Sethi, Gurupreet S. S.
    Gracias, Donald T. T.
    Gupta, Rinkesh K. K.
    Carr, Daniel
    Miki, Haruka
    Da Silva Antunes, Ricardo
    Croft, Michael
    [J]. ALLERGY, 2023, 78 (08) : 2168 - 2180
  • [2] Biased Generation and In Situ Activation of Lung Tissue-Resident Memory CD4 T Cells in the Pathogenesis of Allergic Asthma
    Turner, Damian L.
    Goldklang, Monica
    Cvetkovski, Filip
    Paik, Daniel
    Trischler, Jordis
    Barahona, Josselyn
    Cao, Minwei
    Dave, Ronak
    Tanna, Nicole
    D'Armiento, Jeanine M.
    Farber, Donna L.
    [J]. JOURNAL OF IMMUNOLOGY, 2018, 200 (05): : 1561 - 1569
  • [3] IL-15 supports the generation of lung tissue-resident memory CD4 T cells
    McKinstry, Karl Kai
    Finn, Caroline
    Swain, Susan L.
    [J]. JOURNAL OF IMMUNOLOGY, 2016, 196
  • [4] A novel subset of lung tissue-resident memory CD4 T cells generated by influenza virus infection
    McKinstry, Karl
    Strutt, Tara
    Swain, Susan
    [J]. JOURNAL OF IMMUNOLOGY, 2015, 194
  • [5] CD4 Helpers Put Tissue-Resident Memory Cells in Their Place
    Mackay, Laura K.
    Carbone, Francis R.
    [J]. IMMUNITY, 2014, 41 (04) : 514 - +
  • [6] Cytotoxic CD4+ tissue-resident memory T cells are associated with asthma severity
    Herrera-De La Mata, Sara
    Ramirez-Suastegui, Ciro
    Mistry, Heena
    Castaneda-Castro, Francisco Emmanuel
    Kyyaly, Mohammad A.
    Simon, Hayley
    Liang, Shu
    Lau, Laurie
    Barber, Clair
    Mondal, Monalisa
    Zhang, Hongmei
    Arshad, Syed Hasan
    Kurukulaaratchy, Ramesh J.
    Vijayanand, Pandurangan
    Seumois, Gregory
    [J]. MED, 2023, 4 (12): : 875 - 897.e8
  • [7] Tissue-resident memory T cells and lung immunopathology
    Cheon, In Su
    Son, Young Min
    Sun, Jie
    [J]. IMMUNOLOGICAL REVIEWS, 2023, 316 (01) : 63 - 83
  • [8] Co-Ordination of Mucosal B Cell and CD8 T Cell Memory by Tissue-Resident CD4 Helper T Cells
    Son, Young Min
    Sun, Jie
    [J]. CELLS, 2021, 10 (09)
  • [9] A local macrophage chemokine network sustains protective tissue-resident memory CD4 T cells
    Iijima, Norifumi
    Iwasaki, Akiko
    [J]. SCIENCE, 2014, 346 (6205) : 93 - 98
  • [10] Lung resident memory CD4 T cells promote chronic inflammation in allergic asthma
    Turner, Damian
    Goldklang, Monica
    Trischler, Jordis
    D'Armiento, Jeanine
    Farber, Donna
    [J]. JOURNAL OF IMMUNOLOGY, 2015, 194