Endomicroscopy of the human cochlea using a micro-optical coherence tomography catheter

被引：10
|
作者：
Iyer, Janani S. [1 ,2 ,3 ,4 ,5 ]
Yin, Biwei [4 ,5 ]
Stankovic, Konstantina M. [1 ,2 ,3 ,6 ,7 ,8 ]
Tearney, Guillermo J. [4 ,5 ]
机构：
[1] Massachusetts Eye & Ear, Dept Otolaryngol Head & Neck Surg, 243 Charles St, Boston, MA 02114 USA
[2] Harvard Med Sch, 243 Charles St, Boston, MA 02114 USA
[3] Harvard Univ, Program Speech & Hearing Biosci & Technol, Grad Sch Arts & Sci, 1350 Massachusetts Ave, Cambridge, MA 02138 USA
[4] Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA
[5] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA
[6] Stanford Univ, Dept Otolaryngol Head & Neck Surg, Sch Med, Stanford, CA 94503 USA
[7] Massachusetts Eye & Ear, Dept Otolaryngol Head & Neck Surg, 801 Welch Rd, Stanford, CA 94305 USA
[8] Harvard Med Sch, 801 Welch Rd, Stanford, CA 94305 USA
来源：
SCIENTIFIC REPORTS | 2021年 / 11卷 / 01期
关键词：
DEPTH;
D O I：
10.1038/s41598-021-95991-8
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Sensorineural hearing loss (SNHL) is one of the most profound public health concerns of the modern era, affecting 466 million people today, and projected to affect 900 million by the year 2050. Advances in both diagnostics and therapeutics for SNHL have been impeded by the human cochlea's inaccessibility for in vivo imaging, resulting from its extremely small size, convoluted coiled configuration, fragility, and deep encasement in dense bone. Here, we develop and demonstrate the ability of a sub-millimeter-diameter, flexible endoscopic probe interfaced with a micro-optical coherence tomography (mu OCT) imaging system to enable micron-scale imaging of the inner ear's sensory epithelium in cadaveric human inner ears.
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收藏
页数：7
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