The relationship of miR-181a expression level and AML: A systematic review protocol
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Koolivand, Mohsen
[1
,2
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Moein, Sohaila
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Hormozgan Univ Med Sci, Dept Biochem, Fac Med, Imam Hossein Blvd, Bandar Abbas, Hormozgan, IranHormozgan Univ Med Sci, Student Comm, Bandar Abbas, Hormozgan, Iran
Moein, Sohaila
[2
]
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MalekZadeh, Kianoosh
[3
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[1] Hormozgan Univ Med Sci, Student Comm, Bandar Abbas, Hormozgan, Iran
[2] Hormozgan Univ Med Sci, Dept Biochem, Fac Med, Imam Hossein Blvd, Bandar Abbas, Hormozgan, Iran
[3] Hormozgan Univ Med Sci, Med Genet Dept, Fac Med, Bandar Abbas, Hormozgan, Iran
Introduction: The most common type of leukemia is acute myeloid leukemia (AML) with the lowest survival rate among all of the leukemias particularly in adults. The evidence has shown that dysregulation of miRNA expression is associated with AML. Therefore, the aim of this systematic review was to clarify the role of miR-181a expression in AML. Methods and analysis: In the present study, observational studies of the roles of miR-181a expression in patients with AML will be included. Standards and indicators test should be performed for all patients. We will search PubMed, SCOPUS and ISI Web of Science with no restriction of language. The outcomes will be reviewed for association between miR-181a level and AML progression and the strength of this relationship with AML will be investigated. Selection of articles and data extraction will be performed by two independent reviewers. STROBE will be used for assessment of study quality. Publication bias and data synthesis will be an assessment by funnel plots and Beggs and Egger's tests using Stata software V.12.1. Ethics and dissemination: There are no ethical issues. (C) 2019 The Authors. Published by Elsevier Ltd on behalf of Surgical Associates Ltd.
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Stanford Univ, Div Rheumatol & Immunol, Dept Med, Stanford, CA 94305 USA
Vet Affairs Palo Alto Hlth Care Syst, Dept Med, Palo Alto, CA 94306 USAStanford Univ, Div Rheumatol & Immunol, Dept Med, Stanford, CA 94305 USA
Ye, Zhongde
Li, Guangjin
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Stanford Univ, Div Rheumatol & Immunol, Dept Med, Stanford, CA 94305 USA
Vet Affairs Palo Alto Hlth Care Syst, Dept Med, Palo Alto, CA 94306 USAStanford Univ, Div Rheumatol & Immunol, Dept Med, Stanford, CA 94305 USA
Li, Guangjin
Kim, Chulwoo
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Stanford Univ, Div Rheumatol & Immunol, Dept Med, Stanford, CA 94305 USA
Vet Affairs Palo Alto Hlth Care Syst, Dept Med, Palo Alto, CA 94306 USAStanford Univ, Div Rheumatol & Immunol, Dept Med, Stanford, CA 94305 USA
Kim, Chulwoo
Hu, Bin
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Stanford Univ, Div Rheumatol & Immunol, Dept Med, Stanford, CA 94305 USA
Vet Affairs Palo Alto Hlth Care Syst, Dept Med, Palo Alto, CA 94306 USAStanford Univ, Div Rheumatol & Immunol, Dept Med, Stanford, CA 94305 USA
Hu, Bin
Jadhav, Rohit R.
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Stanford Univ, Div Rheumatol & Immunol, Dept Med, Stanford, CA 94305 USA
Vet Affairs Palo Alto Hlth Care Syst, Dept Med, Palo Alto, CA 94306 USAStanford Univ, Div Rheumatol & Immunol, Dept Med, Stanford, CA 94305 USA
Jadhav, Rohit R.
Weyand, Cornelia M.
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Stanford Univ, Div Rheumatol & Immunol, Dept Med, Stanford, CA 94305 USA
Vet Affairs Palo Alto Hlth Care Syst, Dept Med, Palo Alto, CA 94306 USAStanford Univ, Div Rheumatol & Immunol, Dept Med, Stanford, CA 94305 USA
Weyand, Cornelia M.
Goronzy, Jorg J.
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Stanford Univ, Div Rheumatol & Immunol, Dept Med, Stanford, CA 94305 USA
Vet Affairs Palo Alto Hlth Care Syst, Dept Med, Palo Alto, CA 94306 USAStanford Univ, Div Rheumatol & Immunol, Dept Med, Stanford, CA 94305 USA
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Washington Hosp Ctr, Obstet & Gynecol, Washington, DC 20010 USAWashington Hosp Ctr, Obstet & Gynecol, Washington, DC 20010 USA
Parikh, Toral
Devaney, Joe
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Natl Childrens Hosp, Genet, Washington, DC USAWashington Hosp Ctr, Obstet & Gynecol, Washington, DC 20010 USA
Devaney, Joe
Harmon, Brennan
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Natl Childrens Hosp, Genet, Washington, DC USAWashington Hosp Ctr, Obstet & Gynecol, Washington, DC 20010 USA
Harmon, Brennan
Sullivan, Shannon
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Washington Hosp Ctr, Obstet & Gynecol, Washington, DC 20010 USAWashington Hosp Ctr, Obstet & Gynecol, Washington, DC 20010 USA
Sullivan, Shannon
Gomez-Lobo, Veronica
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Washington Hosp Ctr, Obstet & Gynecol, Washington, DC 20010 USA
Natl Childrens Hosp, Genet, Washington, DC USAWashington Hosp Ctr, Obstet & Gynecol, Washington, DC 20010 USA
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Univ Sao Paulo, Dept Internal Med, Div Hematol, Med Sch Ribeirao Preto, BR-14049 Ribeirao Preto, BrazilUniv Sao Paulo, Dept Internal Med, Div Hematol, Med Sch Ribeirao Preto, BR-14049 Ribeirao Preto, Brazil
Gimenes-Teixeira, Hamilton L.
Zanette, Dalila L.
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Univ Sao Paulo, Dept Genet, Med Sch Ribeirao Preto, BR-14049 Ribeirao Preto, BrazilUniv Sao Paulo, Dept Internal Med, Div Hematol, Med Sch Ribeirao Preto, BR-14049 Ribeirao Preto, Brazil
Zanette, Dalila L.
dos Santos, Guilherme Augusto S.
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Univ Sao Paulo, Dept Internal Med, Div Hematol, Med Sch Ribeirao Preto, BR-14049 Ribeirao Preto, BrazilUniv Sao Paulo, Dept Internal Med, Div Hematol, Med Sch Ribeirao Preto, BR-14049 Ribeirao Preto, Brazil
dos Santos, Guilherme Augusto S.
Scheucher, Priscila S.
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Univ Sao Paulo, Dept Internal Med, Div Hematol, Med Sch Ribeirao Preto, BR-14049 Ribeirao Preto, BrazilUniv Sao Paulo, Dept Internal Med, Div Hematol, Med Sch Ribeirao Preto, BR-14049 Ribeirao Preto, Brazil
Scheucher, Priscila S.
Dalmazzo, Leandro F.
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Univ Sao Paulo, Dept Internal Med, Div Hematol, Med Sch Ribeirao Preto, BR-14049 Ribeirao Preto, BrazilUniv Sao Paulo, Dept Internal Med, Div Hematol, Med Sch Ribeirao Preto, BR-14049 Ribeirao Preto, Brazil
Dalmazzo, Leandro F.
Araujo, Amelia G.
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Univ Sao Paulo, Dept Internal Med, Div Hematol, Med Sch Ribeirao Preto, BR-14049 Ribeirao Preto, BrazilUniv Sao Paulo, Dept Internal Med, Div Hematol, Med Sch Ribeirao Preto, BR-14049 Ribeirao Preto, Brazil
Araujo, Amelia G.
Falcao, Roberto P.
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Univ Sao Paulo, Dept Internal Med, Div Hematol, Med Sch Ribeirao Preto, BR-14049 Ribeirao Preto, BrazilUniv Sao Paulo, Dept Internal Med, Div Hematol, Med Sch Ribeirao Preto, BR-14049 Ribeirao Preto, Brazil
Falcao, Roberto P.
Silva Junior, Wilson A.
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Univ Sao Paulo, Dept Genet, Med Sch Ribeirao Preto, BR-14049 Ribeirao Preto, BrazilUniv Sao Paulo, Dept Internal Med, Div Hematol, Med Sch Ribeirao Preto, BR-14049 Ribeirao Preto, Brazil
Silva Junior, Wilson A.
Rego, Eduardo M.
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Univ Sao Paulo, Dept Internal Med, Div Hematol, Med Sch Ribeirao Preto, BR-14049 Ribeirao Preto, BrazilUniv Sao Paulo, Dept Internal Med, Div Hematol, Med Sch Ribeirao Preto, BR-14049 Ribeirao Preto, Brazil