Review:: Structure-activity relationships in β-defensin peptides

被引：92
|
作者：
Taylor, Karen [1 ]
Barran, Perdita E. [2 ]
Dorin, Julia R. [1 ]
机构：
[1] MRC, Human Genet Unit, Edinburgh EH4 2XU, Midlothian, Scotland
[2] Univ Edinburgh, Sch Chem, Edinburgh EH9 3JJ, Midlothian, Scotland
来源：
BIOPOLYMERS | 2008年 / 90卷 / 01期
基金：
英国工程与自然科学研究理事会;
关键词：
defensin; antimicrobial; structure/activity;
D O I：
10.1002/bip.20900
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The,beta-defensins comprise a large family of small cationic antimicrobial peptides widely distributed in plants, mammals and insects. These cysteine rich peptides display multifunctional properties with implications as potential therapeutic agents. Recent research has highlighted their role in both the innate and adaptive immune systems as well as being novel melanocortin ligands. Studies investigating structure and function provide an insight into the molecular basis of their immunological properties. (C) 2007 Wiley Periodicals, Inc.
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页码：1 / 7
页数：7
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