ROFLUMILAST FOR COPD

Patients with chronic obstructive pulmonary disease (CORD) and chronic bronchitis have a reduction in lung function and a higher risk of suffering exacerbations, which result in a deterioration in their quality of life, an accelerated progression of the disease and a greater mortality. CORD is currently considered an inflammatory disease involving airways and lung parenchyma. The symptoms that are typical of chronic bronchitis (chronic cough and sputum production) are markers of underlying inflammation, characteristic of CORD. Roflumilast, an anti-inflammatory drug that belongs to the new therapeutic class of phosphodiesterase PDE4 inhibitors, is the first to rug developed for the treatment of a specific phenotype of CORD (COPD associated with chronic bronchitis). The results of clinical trials indicated that in patients with CORD associated with chronic bronchitis and a history of exacerbations, roflumilast improves lung function and reduces the frequency of exacerbations that require medical interventions. This effect remained when it was added to a regular treatment with long-acting bronchodilators such as tiotropium or long-acting beta(2)-adrenoceptor agonists (LABAs) such as salmeterol. Roflumilast has been shown to be generally well tolerated. Side effects were typically mild to moderate and included diarrhea, nausea, weight decrease and headache. Gastrointestinal side effects mainly occurred within the first weeks of therapy and mostly resolved on continued treatment.