Association of lamina cribrosa morphometry with retinal nerve fiber layer loss and visual field defects in primary open angle glaucoma

Objectives: To calculate the anterior lamina cribrosa depth (ALCD) and lamina cribrosa thickness (LCT) in primary open angle glaucoma (POAG) patients and controls and to correlate lamina cribrosa (LC) parameters to retinal nerve fiber layer thickness (RNFLT) and visual field (VF) defects. Methods: The study was conducted from November 2018 to March 2019. A total of 60 correspondents (30 cases and 30 controls) were assessed for general ophthalmological investigations including intraocular pressure (IOP), axial length AXL, ophthalmoscopy, visual field (VF) testing and spectral domain ocular computed tomography (SDOCT). Results: The mean age of subjects was 62 years (Cases 67.30 +/- 1.2, controls 57.32 +/- 1.1) with more male participants. Intraocular pressure [IOP (19.85 +/- 1.4)], AXL (22.85 +/- 1.6), VF defects (8.30 +/- 4.5), RNFLT (72.58 +/- 13.2) and LCT (162.51 +/- 64.62) were statistically significant in POAG patients as compared to the controls. Conclusion: A thinner LC in POAG correlated significantly with the RNFLT and VF defects. LC anatomical parameters can be estimated with precision using SDOCT with enhanced depth imaging (EDI).