Daratumumab in life-threatening autoimmune hemolytic anemia following hematopoietic stem cell transplantation

被引：89
|
作者：
Schuetz, Catharina [1 ]
Hoenig, Manfred [1 ]
Moshous, Despina [2 ,3 ]
Weinstock, Christof [4 ]
Castelle, Martin [2 ]
Bendavid, Matthieu [2 ]
Shimano, Kristin [5 ]
Tolbert, Vanessa [5 ]
Schulz, Ansgar S. [1 ]
Dvorak, Christopher C. [5 ]
机构：
[1] Univ Med Ctr Ulm, Dept Pediat & Adolescent Med, Eythstr 24, D-89075 Ulm, Germany
[2] Hop Necker Enfants Malad, AP HP, Unite Immunohematol & Rhumatol Pediat, Paris, France
[3] Univ Paris 05, Imagine Inst, INSERM UMR 1163, Sorbonne Paris Cite, Paris, France
[4] Ulm Univ, Inst Transfus Med, Ulm, Germany
[5] Univ Calif San Francisco, Div Allergy Immunol & Blood & Marrow Transplant, Benioff Childrens Hosp, 550 16th St,4th Floor,Box 0434, San Francisco, CA 94143 USA
来源：
BLOOD ADVANCES | 2018年 / 2卷 / 19期
关键词：
MULTIPLE-MYELOMA; CD38;
D O I：
10.1182/bloodadvances.2018020883
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
New-onset autoimmune hemolytic anemia (AIHA) occurs in 2% to 6% of pediatric patients post-hematopoietic stem cell transplantation (HSCT) and is a significant complication. Incomplete immune recovery following HSCT may predispose to immune dysregulation including autoimmune cytopenias. We describe an innovative therapy for AIHA refractory to proteasome inhibition. In potentially life-threatening AIHA in the context of HSCT, daratumumab may be an effective rescue therapy.
引用
收藏
页码：2550 / 2553
页数：4
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