Surface modified dendrimers: Synthesis and characterization for cancer targeted drug delivery

被引：45
|
作者：
Sharma, Anupama [1 ]
Gautam, Surya Prakash [1 ]
Gupta, Arun Kumar [1 ]
机构：
[1] Smriti Coll Pharmaceut Educ, Indore 452010, MP, India
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2011年 / 19卷 / 11期
关键词：
PAMAM; Gallic acid; Cancer targeting; Surface modified dendrimer; Apoptosis; SENCAR MOUSE SKIN; GALLIC ACID; ANTIOXIDANT ACTIVITY; TUMOR PROMOTION; CELL-CYCLE; APOPTOSIS; INITIATION; FRACTION; RELEASE;
D O I：
10.1016/j.bmc.2011.04.046
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Dendrimers represents a highly branched three-dimensional structure that provides a high degree of surface functionality and versatility. PAMAM dendrimers are used as well-defined nanocontainers to conjugate, complex or encapsulate therapeutic drugs or imaging moieties. Star-burst [PAMAM] dendrimers represent a superior carrier platform for drug delivery. The present study was aimed at synthesis of a surface modified dendrimer for cancer targeted drug delivery system. For this 4.0 G PAMAM dendrimer was conjugated with Gallic acid [GA] and characterized through UV, IR, H-1 NMR and mass spectroscopy. Cytotoxicity study of dendrimer conjugate was carried out against MCF-7 cell line using MTT assay. The study revealed that the conjugate is active against MCF-7 cell line and might act synergistically with anti-cancer drug and gallic acid-dendrimer conjugate might be a promising nano-platform for cancer targeting and cancer diagnosis. (C) 2011 Elsevier Ltd. All rights reserved.
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页码：3341 / 3346
页数：6
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