Palladium-catalyzed domino intramolecular N-arylation/intermolecular C-C bond formation for the synthesis of functionalized benzodiazepinediones

被引：54
|
作者：
Salcedo, Angela [1 ]
Neuville, Luc [1 ]
Rondot, Christophe [1 ]
Retailleau, Pascal [1 ]
Zhu, Jieping [1 ]
机构：
[1] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France
来源：
ORGANIC LETTERS | 2008年 / 10卷 / 05期
关键词：
D O I：
10.1021/ol7029799
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A divergent and regiocontrolled Pd-catalyzed domino sequence involving an intramolecular N-arylation and an intermolecular Heck reaction has been developed, providing rapid access to functionalized benzodiazepine-2,5-diones 3. The starting materials were synthesized by the Ugi four-component reaction. An unprecedented X-ray structure of bispalladacycle 6 was documented.
引用
收藏
页码：857 / 860
页数：4
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