Carriage of Streptococcus pneumoniae 3 Years after Start of Vaccination Program, the Netherlands

被引：84
|
作者：
Spijkerman, Judith [1 ,2 ]
van Gils, Elske J. M. [1 ,2 ]
Veenhoven, Reinier H. [2 ]
Hak, Eelko [3 ]
Yzerman, Ed P. F. [4 ]
van der Ende, Arie [5 ]
Wijmenga-Monsuur, Alienke J. [6 ]
van den Dobbelsteen, Germie P. J. M. [6 ]
Sanders, Elisabeth A. M. [1 ]
机构：
[1] Univ Med Ctr, Utrecht, Netherlands
[2] Spaarne Hosp, Hoofddorp, Netherlands
[3] Univ Groningen, Univ Med Ctr Groningen, NL-9713 AV Groningen, Netherlands
[4] Reg Publ Hlth Lab, Haarlem, Netherlands
[5] Univ Amsterdam, Acad Med Ctr, NL-1105 AZ Amsterdam, Netherlands
[6] Netherlands Vaccine Inst, Bilthoven, Netherlands
来源：
EMERGING INFECTIOUS DISEASES | 2011年 / 17卷 / 04期
关键词：
PNEUMOCOCCAL CONJUGATE VACCINE; ACUTE OTITIS-MEDIA; COMMUNITY-ACQUIRED PNEUMONIA; UNITED-STATES; SEROTYPE; 19A; NASOPHARYNGEAL COLONIZATION; INFANT IMMUNIZATION; INVASIVE DISEASE; CHILDREN YOUNGER; IMPACT;
D O I：
10.3201/eid1704.101115
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
To evaluate the effectiveness of the 7-valent pneumococcal conjugate vaccine (PCV7) program, we conducted a cross-sectional observational study on nasopharyngeal carriage of Streptococcus pneumoniae 3 years after implementation of the program in the Netherlands. We compared pneumococcal serotypes in 329 prebooster 11-month-old children, 330 fully vaccinated 24-month-old children, and 324 parents with age-matched pre-PCV7 (unvaccinated) controls (ages 12 and 24 months, n = 319 and n = 321, respectively) and 296 of their parents. PCV7 serotype prevalences before and after PCV7 implementation, respectively, were 38% and 8% among 11-month-old children, 36% and 4% among 24-month-old children, and 8% and 1% among parents. Non-PCV7 serotype prevalences were 29% and 39% among 11-month-old children, 30% and 45% among 24-month-old children, and 8% and 15% among parents, respectively; serotypes 11A and 19A were most frequently isolated. PCV7 serotypes were largely replaced by non-PCV7 serotypes. Disappearance of PCV7 serotypes in parents suggests strong transmission reduction through vaccination.
引用
收藏
页码：584 / 591
页数：8
相关论文
共 50 条
  • [1] Streptococcus pneumoniae - a review of carriage, infection, serotype replacement and vaccination
    Mehr, Sam
    Wood, Nicholas
    [J]. PAEDIATRIC RESPIRATORY REVIEWS, 2012, 13 (04) : 258 - 264
  • [2] Carriage of Streptococcus pneumoniae in asymptomatic, community-dwelling elderly in the Netherlands
    van Deursen, Anna M. M.
    van den Bergh, Menno R.
    Sanders, Elisabeth A. M.
    [J]. VACCINE, 2016, 34 (01) : 4 - 6
  • [3] Nasal carriage of Streptococcus pneumoniae in elderly subjects according to vaccination status
    Altuzarra, Rogelio
    Valenzuela, M. Teresa
    Trucco, Olivia
    Inostroza, Jaime
    Granata, Paulo
    Fleiderman, Jose
    [J]. REVISTA MEDICA DE CHILE, 2007, 135 (02) : 160 - 166
  • [4] Lower Immunoglobulin G Antibody Responses to Pneumococcal Conjugate Vaccination at the Age of 2 Years after Previous Nasopharyngeal Carriage of Streptococcus pneumoniae
    Rodenburg, Gerwin D.
    van Gils, Elske J. M.
    Veenhoven, Reinier H.
    Bogaert, Debby
    van den Dobbelsteen, Germie P. J. M.
    Berbers, Guy A. M.
    Sanders, Elisabeth A. M.
    [J]. JOURNAL OF PEDIATRICS, 2011, 159 (06): : 965 - U127
  • [5] Have Preferences of Girls Changed Almost 3 Years after the Much Debated Start of the HPV Vaccination Program in the Netherlands? A Discrete Choice Experiment
    Hofman, Robine
    de Bekker-Grob, Esther W.
    Richardus, Jan Hendrik
    de Koning, Harry J.
    van Ballegooijen, Marjolein
    Korfage, Ida J.
    [J]. PLOS ONE, 2014, 9 (08):
  • [6] UNDERSTANDING THE IMMUNE RESPONSE TO STREPTOCOCCUS PNEUMONIAE FROM VACCINATION AND CARRIAGE ON A PROTEOME SCALE
    Campo, Joseph J.
    Croucher, Nicholas J.
    Turner, Paul
    Tate, Andrea
    Le, Tim
    Pablo, Jozelyn
    Hung, Chris
    Teng, Andy
    Hanage, William P.
    Lipsitch, Marc
    Goldblatt, David
    Alderson, Mark
    Liang, Xiaowu
    [J]. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2017, 95 (05): : 367 - 367
  • [7] Carriage of Streptoccoccus pneumoniae 7 years after implementation of vaccination program in a population with very high and long-lasting coverage, Italy
    Ansaldi, Filippo
    de Florentiis, Daniela
    Canepa, Paola
    Zancolli, Marta
    Martini, Mariano
    Orsi, Andrea
    Durando, Paolo
    Icardi, Giancarlo
    [J]. VACCINE, 2012, 30 (13) : 2288 - 2294
  • [8] Impact of Prevnar vaccination on nasopharyngeal carriage of Streptococcus pneumoniae in healthy children in New Caledonia
    Julie Scotet
    Francine Baumann
    Myrielle Dupont-Rouzeyrol
    Catherine Grangeon
    Shahin Oftadeh
    Benoit Garin
    Suzanne Chanteau
    Simon Le Hello
    [J]. BMC Proceedings, 5 (Suppl 1)
  • [9] Nasopharyngeal carriage of Streptococcus pneumoniae and other bacteria in the 7th year after implementation of the pneumococcal conjugate vaccine in the Netherlands
    Bosch, Astrid A. T. M.
    van Houten, Marlies A.
    Bruin, Jacob P.
    Wijmenga-Monsuur, Alienke J.
    Trzcinski, Krzysztof
    Bogaert, Debby
    Rots, Nynke Y.
    Sanders, Elisabeth A. M.
    [J]. VACCINE, 2016, 34 (04) : 531 - 539
  • [10] The impact of a pneumococcal conjugate vaccination program on the nasopharyngeal carriage, serotype distribution and antimicrobial resistance of Streptococcus pneumoniae among healthy children in Turkey
    Soysal, Ahmet
    Karabag-Yilmaz, Esra
    Kepenekli, Eda
    Karaaslan, Ayse
    Cagan, Eren
    Atici, Serkan
    Atinkanat-Gelmez, Gulsen
    Boran, Peran
    Merdan, Selim
    Hasdemir, Ufuk
    Soyletir, Guner
    Bakir, Mustafa
    [J]. VACCINE, 2016, 34 (33) : 3894 - 3900
12345