Apolipoprotein e (APOE) ε4 genotype influences memory performance following remote traumatic brain injury in US military service members and veterans

被引:11
|
作者
Merritt, Victoria C. [1 ,2 ]
Lippa, Rael T. [3 ,4 ,5 ,6 ,7 ,8 ]
Lippa, Sara M. [4 ,5 ]
Brickell, Tracey A. [3 ,4 ,5 ,7 ,8 ,9 ]
Soltis, Anthony R. [10 ,11 ]
Dalgard, Clifton L. [9 ,12 ]
Gill, Jessica M. [13 ]
French, Louis M. [3 ,4 ,5 ,9 ]
机构
[1] VA San Diego Healthcare Syst, 3350 La Jolla Village Dr,MC 151B, San Diego, CA 92161 USA
[2] Univ Calif San Diego, La Jolla, CA 92093 USA
[3] Tramat Brain Injury Ctr Excellence, Silver Spring, MD USA
[4] Walter Reed Natl Mil Med Ctr, Bethesda, MD USA
[5] Natl Intrepid Ctr Excellence, Bethesda, MD USA
[6] Univ British Columbia, Vancouver, BC, Canada
[7] Gen Dynam Informat Technol, Falls Church, VA USA
[8] Ctr Excellence Post Traumat Stress Disorder, Ottawa, ON, Canada
[9] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA
[10] Henry M Jackson Fdn, Bethesda, MD USA
[11] PRIMER, Bethesda, MD USA
[12] Amer Genome Ctr, Bethesda, MD USA
[13] NINR, NIH, Bethesda, MD 20892 USA
关键词
Genetics; Neurocognition; Verbal memory; Military; Neuropsychological assessment; TBI; Head injury; E POLYMORPHISM; NEUROCOGNITIVE PERFORMANCE; ALZHEIMERS-DISEASE; OEF/OIF VETERANS; MODERATE; ALLELE; GENE; MECHANISMS; RECOVERY; SEX;
D O I
10.1016/j.bandc.2021.105790
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The purpose of this study was to examine the association between the apolipoprotein E (APOE) epsilon 4 allele and neurocognitive functioning following traumatic brain injury (TBI) in military service members and veterans (SMVs). Participants included 176 SMVs with a history of remote TBI (>= 1 year post-injury), categorized into mild (n = 100), moderate (n = 40), and severe (n = 36) TBI groups. Participants completed a neuropsychological assessment and APOE genotyping (n = 46 epsilon 4+, n = 130 epsilon 4-). Neurocognitive composite scores representing memory, executive functioning, and visual processing speed were computed. ANCOVAs adjusting for race, education, combat exposure, and PTSD symptom severity showed a significant main effect of epsilon 4 on the memory composite, such that epsilon 4+ SMVs exhibited poorer memory performance than epsilon 4- SMVs. When epsilon 2 allele carriers were removed from the analyses, associations with memory were strengthened, demonstrating a possible protective effect of the epsilon 2 allele. No main effect of TBI group was identified on any cognitive composite, nor were there any significant TBI group x epsilon 4 status interactions for any cognitive composite. Future studies with larger samples are needed to verify these findings, but our results suggest an important relationship between epsilon 4 status and memory functioning following remote TBI of all severities.
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页数:10
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